Basic Information
ID: ALA3888489
Type: Binding
Description: In Vitro PX Assay: HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system (Molecular Devices, LLC, Sunnyvale, Calif.). Compound effects were measured on a partially inactivated state of the sodium channel. Cells were clamped to a holding potential yielding 20 to 50% inactivation. To elicit sodium current, channels were activated by pulsing to −10 mV for 20 msec. This voltage protocol was repeated at a rate of 0.1 Hz throughout the experiment. A single concentration of test compound was applied to cells for a duration of 3 minutes.
Cell type: Sf9
Activity Charts
Bioactivity
Activity Types for Assay ALA3888489
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 476.89 | 4.54 | 4.54 |
| 459.83 | 4.68 | 4.68 |
| 492.56 | 5.15 | 5.15 |
| 453.45 | 3.80 | 3.80 |
| 438.92 | 3.53 | 3.53 |
| 520.35 | 5.26 | 5.26 |
| 475.91 | 4.57 | 4.57 |
| 485.46 | 3.51 | 3.51 |
| 471.48 | 3.99 | 3.99 |
| 515.54 | 3.39 | 3.39 |
| 421.48 | 3.62 | 3.62 |
| 505.31 | 5.13 | 5.13 |
| 416.46 | 3.49 | 3.49 |
| 473.43 | 4.16 | 4.16 |
| 480.49 | 4.75 | 4.75 |
| 435.46 | 3.15 | 3.15 |
| 435.49 | 2.28 | 2.28 |
| 472.47 | 3.90 | 3.90 |
| 495.59 | 4.79 | 4.79 |
| 439.46 | 4.08 | 4.08 |
| 425.89 | 4.27 | 4.27 |
| 539.61 | 4.25 | 4.25 |
| 404.47 | 2.88 | 2.88 |
| 475.90 | 5.15 | 5.15 |
| 471.48 | 4.42 | 4.42 |
| 424.51 | 4.02 | 4.02 |
| 508.51 | 4.28 | 4.28 |
| 416.46 | 3.49 | 3.49 |
| 442.52 | 3.74 | 3.74 |
| 426.52 | 3.91 | 3.91 |
| 416.48 | 2.57 | 2.57 |
| 466.54 | 4.24 | 4.24 |
| 480.49 | 4.75 | 4.75 |
| 404.47 | 2.88 | 2.88 |
| 417.47 | 3.01 | 3.01 |
| 466.47 | 4.36 | 4.36 |
| 468.56 | 4.31 | 4.31 |
| 451.53 | 3.93 | 3.93 |
| 439.46 | 4.08 | 4.08 |
| 500.91 | 5.02 | 5.02 |
| 412.50 | 3.65 | 3.65 |
| 472.47 | 3.90 | 3.90 |
| 518.54 | 5.56 | 5.56 |
| 482.47 | 4.24 | 4.24 |
| 432.91 | 4.00 | 4.00 |
| 494.52 | 5.14 | 5.14 |
| 417.51 | 3.87 | 3.87 |
| 428.50 | 3.38 | 3.38 |
| 453.55 | 3.87 | 3.87 |
| 494.52 | 5.14 | 5.14 |
| 432.91 | 4.00 | 4.00 |
| 387.49 | 3.78 | 3.78 |
| 412.50 | 3.65 | 3.65 |
| 515.31 | 4.59 | 4.59 |
| 430.54 | 4.08 | 4.08 |
| 427.87 | 3.33 | 3.33 |
| 442.44 | 3.89 | 3.89 |
| 537.59 | 4.61 | 4.61 |
| 448.53 | 2.89 | 2.89 |
| 466.54 | 4.66 | 4.66 |
| 429.57 | 4.91 | 4.91 |
| 480.49 | 4.75 | 4.75 |
| 466.47 | 4.36 | 4.36 |
| 441.46 | 4.49 | 4.49 |
| 499.49 | 4.42 | 4.42 |
| 497.57 | 5.29 | 5.29 |
| 492.56 | 5.15 | 5.15 |
| 415.54 | 4.60 | 4.60 |
| 459.83 | 4.68 | 4.68 |
| 484.46 | 4.50 | 4.50 |
| 450.40 | 3.90 | 3.90 |
| 522.53 | 4.29 | 4.29 |
| 469.47 | 4.33 | 4.33 |
| 452.95 | 3.92 | 3.92 |
| 409.44 | 3.75 | 3.75 |
| 446.49 | 3.49 | 3.49 |
| 489.88 | 4.67 | 4.67 |
| 471.48 | 4.68 | 4.68 |
| 433.51 | 3.49 | 3.49 |
| 523.56 | 4.26 | 4.26 |
| 496.49 | 4.37 | 4.37 |
| 421.48 | 3.62 | 3.62 |
| 442.35 | 4.78 | 4.78 |
| 412.50 | 3.65 | 3.65 |
| 416.46 | 3.49 | 3.49 |
| 475.90 | 5.15 | 5.15 |
| 485.46 | 4.03 | 4.03 |
| 492.56 | 5.15 | 5.15 |
| 471.48 | 4.50 | 4.50 |
| 522.57 | 4.87 | 4.87 |
| 536.60 | 5.21 | 5.21 |
| 461.43 | 3.70 | 3.70 |
| 421.93 | 4.44 | 4.44 |
| 405.48 | 3.92 | 3.92 |
| 524.55 | 4.69 | 4.69 |
| 480.49 | 4.75 | 4.75 |
| 423.45 | 2.69 | 2.69 |
| 522.57 | 4.87 | 4.87 |
| 531.56 | 4.55 | 4.55 |
| 408.89 | 3.52 | 3.52 |
| 470.86 | 4.48 | 4.48 |
| 430.54 | 4.08 | 4.08 |
| 442.52 | 3.74 | 3.74 |
| 441.53 | 3.99 | 3.99 |
| 403.49 | 3.48 | 3.48 |
| 374.45 | 2.87 | 2.87 |
| 501.51 | 3.52 | 3.52 |
| 446.51 | 2.34 | 2.34 |
| 428.50 | 3.35 | 3.35 |
| 428.50 | 3.35 | 3.35 |
| 405.48 | 3.92 | 3.92 |
| 517.53 | 4.20 | 4.20 |
| 471.85 | 3.88 | 3.88 |
| 428.50 | 3.35 | 3.35 |
| 421.93 | 4.44 | 4.44 |
| 489.47 | 4.71 | 4.71 |
| 435.46 | 3.15 | 3.15 |
| 476.89 | 4.54 | 4.54 |
| 407.90 | 4.13 | 4.13 |
| 520.52 | 4.35 | 4.35 |
| 441.46 | 4.49 | 4.49 |
| 450.55 | 4.54 | 4.54 |
| 447.54 | 3.50 | 3.50 |
| 432.91 | 4.00 | 4.00 |
| 398.47 | 3.35 | 3.35 |
| 404.47 | 2.88 | 2.88 |
| 412.50 | 3.65 | 3.65 |
| 404.47 | 2.88 | 2.88 |
| 442.44 | 3.89 | 3.89 |
| 517.53 | 4.20 | 4.20 |
| 440.55 | 4.47 | 4.47 |
| 431.54 | 3.70 | 3.70 |
| 444.58 | 4.16 | 4.16 |
| 513.52 | 4.81 | 4.81 |
| 409.44 | 3.75 | 3.75 |
| 519.53 | 4.95 | 4.95 |
| 509.51 | 3.89 | 3.89 |
| 428.50 | 3.35 | 3.35 |
| 421.93 | 4.44 | 4.44 |
| 418.50 | 3.19 | 3.19 |
| 515.54 | 3.39 | 3.39 |
| 443.34 | 4.18 | 4.18 |
| 424.51 | 4.02 | 4.02 |
| 416.46 | 3.49 | 3.49 |
| 421.93 | 4.44 | 4.44 |
| 398.47 | 3.35 | 3.35 |
| 518.54 | 5.63 | 5.63 |
| 623.68 | 5.91 | 5.91 |
| 485.51 | 4.03 | 4.03 |
| 433.51 | 2.50 | 2.50 |
| 457.58 | 4.37 | 4.37 |
| 505.93 | 4.00 | 4.00 |
| 473.91 | 4.73 | 4.73 |
| 519.53 | 4.95 | 4.95 |
| 457.46 | 4.37 | 4.37 |
| 484.46 | 4.50 | 4.50 |
| 373.46 | 3.47 | 3.47 |
| 481.98 | 3.02 | 3.02 |
| 482.47 | 4.24 | 4.24 |
| 451.91 | 3.66 | 3.66 |
| 484.46 | 4.50 | 4.50 |
| 418.50 | 3.27 | 3.27 |
| 456.55 | 4.16 | 4.16 |
| 480.45 | 3.89 | 3.89 |
| 466.47 | 4.36 | 4.36 |
| 519.53 | 4.95 | 4.95 |
| 485.46 | 4.03 | 4.03 |
| 489.93 | 4.60 | 4.60 |
| 467.45 | 3.76 | 3.76 |
| 402.50 | 3.49 | 3.49 |
| 407.90 | 4.13 | 4.13 |
| 413.52 | 4.51 | 4.51 |
| 450.40 | 3.90 | 3.90 |
| 416.46 | 3.49 | 3.49 |
| 405.48 | 3.92 | 3.92 |
| 387.49 | 3.34 | 3.34 |
| 421.93 | 4.44 | 4.44 |
| 430.54 | 4.08 | 4.08 |
| 451.96 | 4.52 | 4.52 |
| 534.55 | 4.53 | 4.53 |
| 516.55 | 4.81 | 4.81 |
| 490.92 | 4.85 | 4.85 |
| 421.93 | 4.44 | 4.44 |
| 520.35 | 5.26 | 5.26 |
| 475.90 | 5.15 | 5.15 |
| 407.90 | 4.13 | 4.13 |
| 521.34 | 4.65 | 4.65 |
| 428.50 | 3.35 | 3.35 |
| 404.47 | 2.88 | 2.88 |
| 493.37 | 5.18 | 5.18 |
| 486.45 | 3.42 | 3.42 |
| 499.49 | 4.42 | 4.42 |
| 517.53 | 4.20 | 4.20 |
| 403.49 | 3.48 | 3.48 |
| 459.83 | 4.68 | 4.68 |
| 451.55 | 2.88 | 2.88 |
| 442.35 | 4.78 | 4.78 |
| 517.53 | 4.20 | 4.20 |
| 470.86 | 4.48 | 4.48 |
| 409.44 | 3.75 | 3.75 |
| 434.50 | 2.89 | 2.89 |
| 425.89 | 4.27 | 4.27 |
| 475.90 | 5.15 | 5.15 |
| 424.51 | 4.02 | 4.02 |
| 399.46 | 2.74 | 2.74 |
| 412.50 | 3.65 | 3.65 |
| 425.50 | 3.42 | 3.42 |
| 534.34 | 4.78 | 4.78 |
| 458.44 | 3.77 | 3.77 |
| 437.93 | 4.14 | 4.14 |
| 454.48 | 3.78 | 3.78 |
| 442.35 | 4.78 | 4.78 |
| 418.50 | 3.19 | 3.19 |
| 442.48 | 2.88 | 2.88 |
| 416.46 | 3.49 | 3.49 |
| 405.48 | 3.92 | 3.92 |
| 433.51 | 3.49 | 3.49 |
| 470.86 | 4.48 | 4.48 |
| 453.45 | 3.80 | 3.80 |
| 431.50 | 3.05 | 3.05 |
| 457.58 | 2.88 | 2.88 |
| 401.51 | 4.04 | 4.04 |
| 412.50 | 3.54 | 3.54 |
| 471.48 | 4.50 | 4.50 |
| 521.55 | 4.89 | 4.89 |
| 489.02 | 4.50 | 4.50 |
| 439.52 | 3.66 | 3.66 |
| 439.52 | 3.66 | 3.66 |
| 451.96 | 4.52 | 4.52 |
| 480.49 | 4.75 | 4.75 |
| 515.54 | 3.39 | 3.39 |
| 442.52 | 3.74 | 3.74 |
| 480.49 | 4.75 | 4.75 |
| 499.49 | 4.42 | 4.42 |