Basic Information
ID: ALA3888979
Type: Binding
Description: Inhibition Assay: The potency of inhibition of compound I and compound II on prostaglandin F2α receptor was assessed by analyzing the affinity of these compounds for recombinant FP receptor expressed in HEK293-EBNA cells. The results show high binding affinity of compound I and compound II to the human receptor. Selectivity of compound II was tested against all eight prostaglandin receptor subtypes. Selectivity was approximately 10-fold versus prostaglandin E receptor 2 (EP2) and higher than 100-fold against other receptors. Testing the effect of 1 μM compound II against a panel of 50 receptors, channels and enzymes binding sites showed high selectivity for FP. The functional characterization of compound II on human FP was performed in transfected HEK293-EBNA cells.
Cell type: EBNA
Activity Charts
Bioactivity
Activity Types for Assay ALA3888979
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 500.62 | 3.80 | 3.80 |
| 599.75 | 4.33 | 4.33 |