Basic Information
ID: ALA3889197
Type: Binding
Description: In Vitro Potency Assay: The compounds were screened for their affinity for PBR using a method adapted from Le Fur et al (Life Sci. 1983; USA 33: 449-57).The compounds to be tested (dissolved in 50mM Tris-HCl, pH 7.4, 10 mM MgCl2 containing 1% DMSO) competed for binding to Wistar rat heart PBR against 0.3 nM [3H]-PK-11195. The reaction was carried out in 50 mM Tris-HCl, pH 7.4 10 mM MgCl2 for 15 minutes at 25° C.
Format: BAO_0000357
Organism: Rattus norvegicus
Target: Peripheral-type benzodiazepine receptor(ALA4552)
Document: ALA3886988
BindingDB Source: 8489
Activity Charts
Bioactivity
Activity Types for Assay ALA3889197
Ki
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 382.50 | 5.29 | 5.29 |
| 412.53 | 5.30 | 5.30 |
| 400.49 | 5.43 | 5.43 |
| 400.49 | 5.43 | 5.43 |
| 426.56 | 5.69 | 5.69 |
| 412.53 | 5.30 | 5.30 |
| 412.53 | 5.30 | 5.30 |
| 412.53 | 5.30 | 5.30 |