Basic Information
ID: ALA3889303
Type: Binding
Description: Inhibition Assay: To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV1 (hTRPV1) channels and the rat TRPV6 (rTRPV6) channel were also stably transfected and expressed or induced to express in mammalian cell lines. The methods for measuring currents from these channels are well-established and have been described in numerous publications (See, Weerapura et al., 2002, J Physiology 540: 15-27; Rush et al., 2005, J Physiology 564: 808-815; Caterina et al., 1997, Nature 389: 816-824; Hoenderhop et al., 2001, J Physiology 537: 747-761; Clapham et al., 2003, Pharmacol Rev 55: 591-596).
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3889303
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 326.47 | 4.08 | 4.08 |
| 366.41 | 4.48 | 4.48 |
| 323.42 | 3.33 | 3.33 |
| 298.41 | 3.46 | 3.46 |
| 312.44 | 3.77 | 3.77 |
| 332.86 | 4.11 | 4.11 |
| 323.42 | 3.33 | 3.33 |
| 323.42 | 3.33 | 3.33 |
| 394.46 | 5.04 | 5.04 |
| 377.31 | 4.22 | 4.22 |
| 366.41 | 4.48 | 4.48 |
| 352.38 | 4.17 | 4.17 |
| 332.86 | 4.11 | 4.11 |
| 400.85 | 5.13 | 5.13 |
| 384.40 | 4.62 | 4.62 |
| 367.30 | 4.77 | 4.77 |
| 390.89 | 3.90 | 3.90 |
| 326.47 | 4.08 | 4.08 |
| 318.83 | 3.81 | 3.81 |
| 348.86 | 3.82 | 3.82 |