Basic Information
ID: ALA3987223
Type: Binding
Description: Compound was evaluated for the inhibition of human HMBS at 100uM
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3987223
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 337.35 | 1.12 | 1.12 |
| 581.58 | -8.16 | -8.16 |
| 309.33 | 4.44 | 4.44 |
| 340.43 | 2.88 | 2.88 |
| 924.09 | 0.71 | 0.71 |
| 259.35 | 2.78 | 2.78 |
| 260.25 | 1.11 | 1.11 |
| 407.58 | 5.68 | 5.68 |
| 1297.30 | ||
| 199.30 | 0.70 | 0.70 |
| 295.30 | 2.97 | 2.97 |
| 353.42 | 1.84 | 1.84 |
| 287.30 | 0.64 | 0.64 |
| 182.17 | -0.23 | -0.23 |
| 403.27 | 4.53 | 4.53 |
| 343.52 | 4.87 | 4.87 |
| 312.41 | 2.53 | 2.53 |
| 403.27 | 4.13 | 4.13 |
| 396.95 | 3.15 | 3.15 |
| 359.82 | 3.08 | 3.08 |
| 311.41 | 2.41 | 2.41 |
| 306.37 | 3.94 | 3.94 |
| 473.41 | 7.49 | 7.49 |
| 378.32 | 4.45 | 4.45 |
| 335.43 | 4.69 | 4.69 |
| 340.77 | 3.80 | 3.80 |
| 700.79 | 4.57 | 4.57 |
| 466.43 | -1.58 | -1.58 |
| 307.29 | 2.23 | 2.23 |
| 435.33 | 4.67 | 4.67 |
| 534.49 | 4.97 | 4.97 |
| 444.44 | -0.35 | -0.35 |
| 555.52 | 7.13 | 7.13 |
| 357.42 | 2.71 | 2.71 |
| 263.30 | 3.29 | 3.29 |
| 359.26 | 2.67 | 2.67 |
| 403.39 | 4.09 | 4.09 |
| 410.54 | 4.64 | 4.64 |
| 320.39 | 4.76 | 4.76 |
| 335.41 | 3.70 | 3.70 |
| 321.38 | 3.71 | 3.71 |
| 420.51 | 4.93 | 4.93 |
| 320.40 | 3.28 | 3.28 |
| 474.57 | 2.64 | 2.64 |
| 366.90 | 3.58 | 3.58 |
| 168.58 | 2.06 | 2.06 |
| 371.47 | 3.38 | 3.38 |
| 406.27 | 4.67 | 4.67 |
| 371.39 | 2.58 | 2.58 |
| 360.42 | 2.81 | 2.81 |
| 358.35 | 4.45 | 4.45 |
| 441.40 | 4.81 | 4.81 |
| 344.34 | 4.21 | 4.21 |
| 338.84 | 4.18 | 4.18 |
| 402.91 | 3.56 | 3.56 |
| 364.88 | 4.57 | 4.57 |
| 362.36 | 3.77 | 3.77 |
| 237.26 | 3.00 | 3.00 |
| 334.83 | 3.82 | 3.82 |
| 294.40 | 4.16 | 4.16 |
| 269.35 | 2.39 | 2.39 |
| 372.47 | 3.94 | 3.94 |
| 311.74 | 2.65 | 2.65 |
| 370.43 | 3.12 | 3.12 |
| 328.38 | 3.90 | 3.90 |
| 386.80 | 4.66 | 4.66 |
| 429.53 | 2.85 | 2.85 |
| 367.54 | 3.56 | 3.56 |
| 402.54 | 4.20 | 4.20 |
| 358.83 | 2.71 | 2.71 |
| 310.78 | 4.64 | 4.64 |
| 359.39 | 3.79 | 3.79 |
| 374.44 | 4.28 | 4.28 |
| 352.38 | 1.73 | 1.73 |
| 410.50 | 2.53 | 2.53 |
| 397.48 | 2.01 | 2.01 |
| 394.92 | 3.97 | 3.97 |
| 387.44 | 3.32 | 3.32 |
| 382.44 | 4.35 | 4.35 |
| 415.49 | 4.96 | 4.96 |
| 413.50 | 3.83 | 3.83 |
| 420.40 | 2.85 | 2.85 |
| 436.99 | 3.62 | 3.62 |
| 428.32 | 4.36 | 4.36 |
| 381.45 | 3.90 | 3.90 |
| 429.55 | 5.35 | 5.35 |
| 414.51 | 5.16 | 5.16 |
| 291.40 | 4.01 | 4.01 |
| 370.80 | 3.65 | 3.65 |
| 443.33 | 3.99 | 3.99 |
| 380.88 | 4.55 | 4.55 |
| 366.47 | 1.01 | 1.01 |
| 332.37 | 2.46 | 2.46 |
| 417.51 | 3.76 | 3.76 |
| 400.53 | 4.90 | 4.90 |
| 372.43 | 4.36 | 4.36 |
| 370.43 | 1.78 | 1.78 |
| 385.39 | 4.26 | 4.26 |
| 309.39 | 3.11 | 3.11 |
| 399.84 | 2.64 | 2.64 |
| 424.57 | 3.14 | 3.14 |
| 412.29 | 4.83 | 4.83 |
| 437.97 | 4.54 | 4.54 |
| 385.47 | 4.03 | 4.03 |
| 407.58 | 2.30 | 2.30 |
| 449.62 | 4.02 | 4.02 |
| 420.49 | 4.32 | 4.32 |
| 379.44 | 3.06 | 3.06 |
| 380.54 | 4.20 | 4.20 |
| 417.39 | 3.42 | 3.42 |
| 416.52 | 3.93 | 3.93 |
| 354.54 | 4.13 | 4.13 |
| 280.38 | 4.00 | 4.00 |
| 361.47 | 3.03 | 3.03 |
| 278.31 | 3.90 | 3.90 |
| 365.91 | 3.24 | 3.24 |
| 260.30 | 3.13 | 3.13 |
| 335.45 | 3.43 | 3.43 |
| 345.86 | 4.07 | 4.07 |
| 379.38 | 3.89 | 3.89 |
| 410.46 | 2.06 | 2.06 |
| 432.92 | 3.71 | 3.71 |
| 388.48 | 2.46 | 2.46 |
| 323.78 | 4.05 | 4.05 |
| 439.48 | 3.25 | 3.25 |
| 349.83 | 4.81 | 4.81 |
| 354.41 | 2.93 | 2.93 |
| 277.37 | 4.31 | 4.31 |
| 321.42 | 3.13 | 3.13 |
| 358.73 | 4.35 | 4.35 |
| 324.38 | 3.01 | 3.01 |
| 416.55 | 5.10 | 5.10 |
| 364.45 | 3.83 | 3.83 |
| 460.59 | 2.57 | 2.57 |
| 336.78 | 4.05 | 4.05 |
| 331.42 | 3.91 | 3.91 |
| 300.27 | 2.74 | 2.74 |
| 330.56 | 4.68 | 4.68 |
| 231.26 | 0.85 | 0.85 |
| 424.88 | 4.15 | 4.15 |
| 348.41 | 2.27 | 2.27 |
| 329.36 | 4.33 | 4.33 |
| 409.56 | 4.10 | 4.10 |
| 374.40 | 3.41 | 3.41 |
| 321.83 | 4.26 | 4.26 |
| 399.93 | 2.31 | 2.31 |
| 445.97 | 3.72 | 3.72 |
| 378.48 | 3.72 | 3.72 |
| 316.40 | 2.91 | 2.91 |
| 351.19 | 3.79 | 3.79 |
| 391.43 | 2.32 | 2.32 |
| 384.52 | 3.17 | 3.17 |
| 335.40 | 2.60 | 2.60 |
| 414.96 | 3.26 | 3.26 |
| 315.34 | 2.36 | 2.36 |
| 377.51 | 4.02 | 4.02 |
| 316.32 | 2.46 | 2.46 |
| 424.52 | 3.89 | 3.89 |
| 421.50 | 4.82 | 4.82 |
| 253.22 | -1.79 | -1.79 |
| 387.45 | 1.64 | 1.64 |
| 387.45 | 1.64 | 1.64 |
| 335.37 | 1.51 | 1.51 |
| 368.23 | 3.27 | 3.27 |
| 387.45 | 1.64 | 1.64 |
| 204.31 | -0.29 | -0.29 |
| 495.44 | 3.62 | 3.62 |
| 372.48 | 3.15 | 3.15 |
| 313.36 | 2.67 | 2.67 |
| 307.33 | 4.01 | 4.01 |
| 297.33 | 3.43 | 3.43 |
| 343.43 | 3.15 | 3.15 |
| 384.30 | 3.14 | 3.14 |
| 373.50 | 3.60 | 3.60 |
| 204.23 | 1.29 | 1.29 |
| 357.44 | 4.64 | 4.64 |
| 254.27 | 0.07 | 0.07 |
| 325.39 | 3.61 | 3.61 |
| 335.36 | 3.22 | 3.22 |
| 437.46 | 4.38 | 4.38 |
| 334.43 | 3.50 | 3.50 |
| 240.31 | 2.76 | 2.76 |
| 239.25 | 0.73 | 0.73 |
| 222.56 | 1.80 | 1.80 |
| 318.13 | 2.89 | 2.89 |
| 307.31 | 1.91 | 1.91 |
| 364.40 | 3.12 | 3.12 |
| 283.76 | 4.20 | 4.20 |
| 258.39 | 3.64 | 3.64 |
| 314.86 | 4.07 | 4.07 |
| 314.79 | 3.53 | 3.53 |
| 332.36 | 3.25 | 3.25 |
| 433.89 | 4.26 | 4.26 |
| 281.36 | 3.76 | 3.76 |
| 337.42 | 3.93 | 3.93 |
| 279.35 | 3.33 | 3.33 |
| 376.84 | 5.64 | 5.64 |
| 308.38 | 3.83 | 3.83 |
| 367.71 | 4.66 | 4.66 |
| 384.52 | 5.56 | 5.56 |
| 339.83 | 4.05 | 4.05 |
| 325.24 | 4.89 | 4.89 |
| 450.57 | 2.82 | 2.82 |
| 464.60 | 3.21 | 3.21 |
| 377.45 | 2.34 | 2.34 |
| 384.91 | 3.47 | 3.47 |
| 397.95 | 4.69 | 4.69 |
| 308.41 | 3.78 | 3.78 |
| 329.36 | 3.36 | 3.36 |
| 359.44 | 2.62 | 2.62 |
| 326.79 | 3.79 | 3.79 |
| 525.01 | 5.12 | 5.12 |
| 267.34 | 2.83 | 2.83 |
| 416.53 | 3.97 | 3.97 |
| 350.65 | 3.50 | 3.50 |
| 474.54 | 4.45 | 4.45 |
| 349.83 | 4.10 | 4.10 |
| 256.23 | 3.15 | 3.15 |
| 305.38 | 4.22 | 4.22 |
| 349.43 | 3.98 | 3.98 |
| 219.68 | 3.06 | 3.06 |
| 299.76 | 3.23 | 3.23 |
| 352.39 | 3.58 | 3.58 |
| 383.84 | 5.15 | 5.15 |
| 435.60 | 4.03 | 4.03 |
| 365.43 | 5.30 | 5.30 |
| 419.37 | 4.75 | 4.75 |
| 385.26 | 4.00 | 4.00 |
| 319.41 | 3.79 | 3.79 |
| 320.38 | 3.60 | 3.60 |
| 336.39 | 3.25 | 3.25 |
| 383.48 | 3.11 | 3.11 |
| 335.36 | 3.79 | 3.79 |
| 267.35 | 2.12 | 2.12 |
| 349.41 | 3.10 | 3.10 |
| 302.83 | 4.55 | 4.55 |
| 346.22 | 4.42 | 4.42 |
| 347.40 | 3.64 | 3.64 |
| 385.82 | 5.42 | 5.42 |
| 388.18 | 4.59 | 4.59 |
| 336.44 | 4.78 | 4.78 |
| 368.44 | 1.98 | 1.98 |
| 465.55 | 3.93 | 3.93 |
| 339.42 | 3.97 | 3.97 |
| 475.62 | 4.54 | 4.54 |
| 458.48 | 5.04 | 5.04 |
| 302.38 | 3.86 | 3.86 |
| 345.87 | 4.35 | 4.35 |
| 433.44 | 4.74 | 4.74 |
| 344.84 | 4.00 | 4.00 |
| 344.78 | 3.70 | 3.70 |
| 377.49 | 3.46 | 3.46 |
| 320.33 | 4.14 | 4.14 |
| 356.47 | 4.68 | 4.68 |
| 443.66 | 4.52 | 4.52 |
| 427.61 | 3.97 | 3.97 |
| 386.86 | 4.48 | 4.48 |
| 426.52 | 3.78 | 3.78 |
| 448.55 | 4.25 | 4.25 |
| 546.67 | 5.41 | 5.41 |
| 421.54 | 4.96 | 4.96 |
| 292.26 | 3.80 | 3.80 |
| 383.88 | 4.67 | 4.67 |
| 383.68 | 5.34 | 5.34 |
| 357.80 | 2.78 | 2.78 |
| 333.80 | 3.55 | 3.55 |
| 584.72 | 5.96 | 5.96 |
| 334.72 | 3.98 | 3.98 |
| 346.81 | 3.51 | 3.51 |
| 298.43 | 4.63 | 4.63 |
| 442.64 | 1.90 | 1.90 |
| 343.39 | 4.63 | 4.63 |
| 393.83 | 4.95 | 4.95 |
| 678.49 | ||
| 289.38 | 4.29 | 4.29 |
| 431.39 | 3.32 | 3.32 |
| 321.06 | ||
| 466.43 | 6.32 | 6.32 |
| 459.90 | 5.23 | 5.23 |
| 353.43 | 2.93 | 2.93 |
| 401.45 | 5.06 | 5.06 |
| 326.44 | 5.12 | 5.12 |
| 375.43 | 3.50 | 3.50 |
| 557.02 | 6.76 | 6.76 |
| 365.45 | 3.94 | 3.94 |
| 312.34 | 2.07 | 2.07 |
| 313.79 | 3.53 | 3.53 |
| 337.38 | 3.25 | 3.25 |
| 458.54 | 2.16 | 2.16 |
| 364.24 | 3.09 | 3.09 |
| 269.30 | 2.68 | 2.68 |
| 422.50 | 4.60 | 4.60 |
| 232.24 | 2.10 | 2.10 |
| 354.39 | 3.33 | 3.33 |
| 297.40 | 3.11 | 3.11 |
| 351.41 | 2.52 | 2.52 |
| 331.39 | 3.61 | 3.61 |
| 490.59 | 3.33 | 3.33 |
| 474.59 | 3.63 | 3.63 |
| 313.23 | 2.07 | 2.07 |
| 424.93 | 4.19 | 4.19 |
| 343.38 | 2.04 | 2.04 |
| 339.85 | 3.02 | 3.02 |
| 267.38 | 2.22 | 2.22 |
| 321.40 | 2.31 | 2.31 |
| 408.95 | 4.15 | 4.15 |
| 319.79 | 4.06 | 4.06 |
| 422.33 | 3.28 | 3.28 |
| 335.44 | 4.26 | 4.26 |
| 387.49 | 3.07 | 3.07 |
| 341.36 | 4.20 | 4.20 |
| 467.47 | 4.65 | 4.65 |
| 438.46 | 2.36 | 2.36 |
| 358.37 | 2.45 | 2.45 |
| 252.27 | 2.09 | 2.09 |
| 321.17 | 3.72 | 3.72 |
| 317.77 | 3.82 | 3.82 |
| 345.44 | 2.58 | 2.58 |
| 364.49 | 4.67 | 4.67 |
| 299.37 | 3.72 | 3.72 |
| 374.28 | 4.91 | 4.91 |
| 424.91 | 5.89 | 5.89 |
| 380.44 | 4.62 | 4.62 |
| 371.47 | 5.03 | 5.03 |
| 336.19 | 3.01 | 3.01 |
| 400.43 | 3.57 | 3.57 |
| 534.52 | 2.95 | 2.95 |
| 275.31 | -0.90 | -0.90 |
| 412.50 | 3.48 | 3.48 |
| 276.36 | 3.40 | 3.40 |
| 393.47 | 4.15 | 4.15 |
| 330.37 | 1.64 | 1.64 |
| 435.55 | 3.56 | 3.56 |
| 442.19 | 4.84 | 4.84 |
| 320.44 | 3.36 | 3.36 |
| 369.35 | 4.65 | 4.65 |
| 329.35 | 2.65 | 2.65 |
| 310.38 | 3.12 | 3.12 |
| 316.36 | 4.38 | 4.38 |
| 356.44 | 3.81 | 3.81 |
| 356.44 | 3.81 | 3.81 |
| 400.19 | 4.53 | 4.53 |
| 415.54 | 4.76 | 4.76 |
| 315.80 | 3.73 | 3.73 |
| 499.60 | 3.85 | 3.85 |
| 328.46 | 2.57 | 2.57 |
| 327.45 | 4.52 | 4.52 |
| 339.40 | 4.09 | 4.09 |
| 330.39 | 4.25 | 4.25 |
| 355.47 | 3.31 | 3.31 |
| 375.46 | 3.58 | 3.58 |
| 418.29 | 5.62 | 5.62 |
| 431.97 | 2.46 | 2.46 |
| 494.03 | 4.64 | 4.64 |
| 324.57 | 3.02 | 3.02 |
| 469.45 | 5.20 | 5.20 |
| 394.84 | 5.33 | 5.33 |
| 521.98 | 5.02 | 5.02 |
| 495.01 | 4.02 | 4.02 |
| 449.77 | 5.83 | 5.83 |
| 433.55 | 1.68 | 1.68 |
| 437.50 | 2.38 | 2.38 |
| 408.38 | 4.17 | 4.17 |
| 349.44 | 2.66 | 2.66 |
| 417.47 | 3.58 | 3.58 |
| 244.29 | 3.33 | 3.33 |
| 447.36 | 6.47 | 6.47 |
| 462.04 | ||
| 609.21 | ||
| 384.28 | 4.83 | 4.83 |
| 352.48 | 4.55 | 4.55 |
| 376.43 | 4.53 | 4.53 |
| 340.47 | 4.73 | 4.73 |
| 284.36 | 2.99 | 2.99 |
| 334.39 | 4.58 | 4.58 |
| 489.64 | 7.64 | 7.64 |
| 360.44 | 3.19 | 3.19 |
| 327.31 | 2.99 | 2.99 |
| 363.42 | 6.08 | 6.08 |
| 373.46 | 5.20 | 5.20 |
| 359.43 | 4.86 | 4.86 |
| 353.47 | 5.42 | 5.42 |
| 325.44 | 4.30 | 4.30 |
| 325.48 | 3.87 | 3.87 |
| 351.84 | 2.93 | 2.93 |
| 461.52 | 3.43 | 3.43 |
| 393.39 | 4.54 | 4.54 |
| 369.73 | 5.40 | 5.40 |
| 339.40 | 2.71 | 2.71 |
| 343.90 | 5.10 | 5.10 |
| 459.55 | 4.27 | 4.27 |
| 275.32 | 2.68 | 2.68 |
| 455.53 | 6.40 | 6.40 |
| 391.30 | 5.08 | 5.08 |
| 465.51 | 4.32 | 4.32 |
| 457.00 | 5.58 | 5.58 |
| 451.87 | 3.26 | 3.26 |
| 822.95 | 2.45 | 2.45 |
| 585.61 | -8.42 | -8.42 |
| 740.76 | 1.54 | 1.54 |