Basic Information
ID: ALA3988182
Type: Functional
Description: GSK PKIS2: Screen against O. lienalis microfilariae, single point, at 3.1uM to assess reduction in motility. Compounds were also tested for cytotoxicity against Rhesus Monkey LLCMK2 cells. A score was assigned as follows: Score 3 = Good activity, 100 % motility reduction; Score 2 = Marginal/moderate activity, 50-99% motility reduction; Score 1 = Inactive, <50% motility reduction; Score 0 = Cytotoxic.
Organism: Onchocerca lienalis
Strain: Microfilariae
Cell type: LLC-MK2
Activity Charts
Bioactivity
Activity Types for Assay ALA3988182
MOTILITY REDUCTION/CYTOTOXICITY
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 359.36 | 4.64 | 4.64 |
| 491.57 | 6.53 | 6.53 |
| 397.45 | 2.88 | 2.88 |
| 443.53 | 5.48 | 5.48 |
| 443.53 | 5.48 | 5.48 |
| 343.39 | 4.66 | 4.66 |
| 393.44 | 4.35 | 4.35 |
| 360.21 | 4.15 | 4.15 |
| 485.95 | 4.39 | 4.39 |
| 350.43 | 5.38 | 5.38 |
| 351.41 | 4.77 | 4.77 |
| 351.41 | 4.77 | 4.77 |
| 252.28 | 2.58 | 2.58 |
| 512.44 | 5.77 | 5.77 |
| 267.34 | 2.70 | 2.70 |
| 261.29 | 2.55 | 2.55 |
| 275.40 | 3.33 | 3.33 |
| 211.23 | 1.60 | 1.60 |
| 233.32 | 2.33 | 2.33 |
| 253.31 | 2.46 | 2.46 |
| 241.25 | 1.41 | 1.41 |
| 245.67 | 2.05 | 2.05 |
| 241.25 | 1.41 | 1.41 |
| 226.24 | 1.18 | 1.18 |
| 149.16 | -0.05 | -0.05 |
| 191.24 | 1.16 | 1.16 |
| 287.33 | 3.06 | 3.06 |
| 239.25 | 3.28 | 3.28 |
| 313.36 | 4.51 | 4.51 |
| 327.39 | 4.81 | 4.81 |
| 297.36 | 3.86 | 3.86 |
| 380.47 | 3.77 | 3.77 |
| 420.41 | 3.93 | 3.93 |
| 414.49 | 4.81 | 4.81 |
| 367.43 | 3.47 | 3.47 |
| 428.51 | 4.57 | 4.57 |
| 410.45 | 3.52 | 3.52 |
| 366.44 | 3.45 | 3.45 |
| 332.36 | 2.61 | 2.61 |
| 527.67 | 5.99 | 5.99 |
| 267.29 | 3.17 | 3.17 |
| 466.34 | 4.44 | 4.44 |
| 313.31 | 3.86 | 3.86 |
| 295.32 | 3.72 | 3.72 |
| 283.36 | 3.64 | 3.64 |
| 413.52 | 3.59 | 3.59 |
| 396.47 | 2.76 | 2.76 |
| 381.46 | 3.18 | 3.18 |
| 396.47 | 2.91 | 2.91 |
| 366.44 | 3.47 | 3.47 |
| 307.42 | 4.28 | 4.28 |
| 416.45 | 4.35 | 4.35 |
| 366.44 | 3.47 | 3.47 |
| 340.40 | 2.90 | 2.90 |
| 342.74 | 2.52 | 2.52 |
| 397.64 | 4.17 | 4.17 |
| 344.82 | 3.54 | 3.54 |
| 391.21 | 3.51 | 3.51 |
| 338.32 | 1.87 | 1.87 |
| 278.31 | 2.51 | 2.51 |
| 328.76 | 2.83 | 2.83 |
| 298.73 | 2.82 | 2.82 |
| 333.17 | 3.47 | 3.47 |
| 280.28 | 1.87 | 1.87 |
| 328.76 | 2.83 | 2.83 |
| 344.82 | 3.54 | 3.54 |
| 314.73 | 2.53 | 2.53 |
| 344.82 | 3.54 | 3.54 |
| 342.74 | 2.52 | 2.52 |
| 379.20 | 3.19 | 3.19 |
| 314.73 | 2.53 | 2.53 |
| 344.75 | 2.53 | 2.53 |
| 349.17 | 3.18 | 3.18 |
| 338.32 | 1.87 | 1.87 |
| 349.17 | 3.18 | 3.18 |
| 310.31 | 1.88 | 1.88 |
| 324.77 | 2.77 | 2.77 |
| 324.77 | 2.77 | 2.77 |
| 308.34 | 2.20 | 2.20 |
| 298.73 | 2.82 | 2.82 |
| 310.31 | 1.88 | 1.88 |
| 310.31 | 1.88 | 1.88 |
| 278.31 | 2.19 | 2.19 |
| 333.17 | 3.47 | 3.47 |
| 372.76 | 2.53 | 2.53 |
| 342.74 | 2.52 | 2.52 |
| 419.85 | 5.39 | 5.39 |
| 304.38 | 4.00 | 4.00 |
| 304.38 | 4.00 | 4.00 |
| 321.38 | 4.75 | 4.75 |
| 310.41 | 4.06 | 4.06 |
| 500.41 | 6.63 | 6.63 |
| 434.84 | 5.53 | 5.53 |
| 456.89 | 5.02 | 5.02 |
| 435.21 | 4.71 | 4.71 |
| 370.34 | 4.26 | 4.26 |
| 501.30 | 6.92 | 6.92 |
| 575.55 | 5.44 | 5.44 |
| 223.28 | 3.12 | 3.12 |
| 309.13 | 1.85 | 1.85 |
| 213.24 | 2.71 | 2.71 |
| 229.24 | 1.69 | 1.69 |
| 342.41 | 0.92 | 0.92 |
| 243.27 | 2.00 | 2.00 |
| 622.80 | 3.40 | 3.40 |
| 614.78 | 4.92 | 4.92 |
| 240.27 | 2.22 | 2.22 |
| 376.41 | 4.03 | 4.03 |
| 347.37 | 4.16 | 4.16 |
| 342.83 | 3.73 | 3.73 |
| 347.81 | 5.16 | 5.16 |
| 513.60 | 4.74 | 4.74 |
| 411.47 | 3.67 | 3.67 |
| 328.38 | 4.21 | 4.21 |
| 312.38 | 4.51 | 4.51 |
| 366.35 | 5.22 | 5.22 |
| 332.79 | 4.85 | 4.85 |
| 439.52 | 4.45 | 4.45 |
| 323.36 | 4.07 | 4.07 |
| 385.47 | 4.14 | 4.14 |
| 366.35 | 5.22 | 5.22 |
| 397.48 | 4.03 | 4.03 |
| 312.38 | 4.51 | 4.51 |
| 298.35 | 4.20 | 4.20 |
| 312.38 | 4.51 | 4.51 |
| 395.47 | 4.44 | 4.44 |
| 563.08 | 6.00 | 6.00 |
| 432.38 | 4.24 | 4.24 |
| 403.46 | 2.76 | 2.76 |
| 503.41 | 6.34 | 6.34 |
| 519.87 | 6.85 | 6.85 |
| 453.41 | 5.46 | 5.46 |
| 463.52 | 5.90 | 5.90 |
| 502.42 | 5.87 | 5.87 |
| 504.40 | 5.73 | 5.73 |
| 517.44 | 6.35 | 6.35 |
| 539.45 | 7.00 | 7.00 |
| 571.58 | 5.82 | 5.82 |
| 419.53 | 7.09 | 7.09 |
| 431.35 | 5.27 | 5.27 |
| 279.30 | 2.14 | 2.14 |
| 272.31 | 3.69 | 3.69 |
| 294.31 | 2.68 | 2.68 |
| 363.24 | 3.80 | 3.80 |
| 391.29 | 4.58 | 4.58 |
| 487.40 | 3.45 | 3.45 |
| 294.31 | 2.68 | 2.68 |
| 357.21 | 3.74 | 3.74 |
| 210.24 | 2.21 | 2.21 |
| 287.33 | 3.27 | 3.27 |
| 211.23 | 1.60 | 1.60 |
| 210.24 | 2.21 | 2.21 |
| 267.29 | 3.17 | 3.17 |
| 283.36 | 3.64 | 3.64 |
| 295.32 | 3.72 | 3.72 |
| 312.76 | 3.63 | 3.63 |
| 294.31 | 2.68 | 2.68 |
| 308.34 | 2.98 | 2.98 |
| 308.34 | 2.98 | 2.98 |
| 330.39 | 4.52 | 4.52 |
| 278.32 | 2.97 | 2.97 |
| 204.23 | 1.70 | 1.70 |
| 392.28 | 3.97 | 3.97 |
| 364.23 | 3.19 | 3.19 |
| 163.18 | 0.42 | 0.42 |
| 347.42 | 4.16 | 4.16 |
| 294.31 | 3.72 | 3.72 |
| 462.53 | 4.64 | 4.64 |
| 399.45 | 5.28 | 5.28 |
| 598.13 | 6.00 | 6.00 |
| 569.72 | 5.03 | 5.03 |
| 580.14 | 5.86 | 5.86 |
| 286.34 | 1.00 | 1.00 |
| 379.42 | 2.48 | 2.48 |
| 399.46 | 1.32 | 1.32 |
| 415.52 | 4.16 | 4.16 |
| 449.94 | 4.50 | 4.50 |
| 450.93 | 6.80 | 6.80 |
| 410.46 | 3.18 | 3.18 |
| 379.44 | 3.77 | 3.77 |
| 367.41 | 3.90 | 3.90 |
| 397.89 | 4.73 | 4.73 |
| 437.52 | 4.21 | 4.21 |
| 376.50 | 4.47 | 4.47 |
| 352.41 | 3.52 | 3.52 |
| 390.44 | 4.35 | 4.35 |
| 483.62 | 4.20 | 4.20 |
| 468.60 | 5.44 | 5.44 |
| 499.60 | 4.34 | 4.34 |
| 444.54 | 3.47 | 3.47 |
| 490.57 | 2.07 | 2.07 |
| 308.39 | 3.10 | 3.10 |
| 442.57 | 4.02 | 4.02 |
| 454.46 | 3.70 | 3.70 |
| 277.33 | 3.65 | 3.65 |
| 307.30 | 4.34 | 4.34 |
| 303.34 | 4.51 | 4.51 |
| 303.34 | 4.51 | 4.51 |
| 303.34 | 4.51 | 4.51 |
| 387.34 | 5.14 | 5.14 |
| 316.39 | 1.47 | 1.47 |
| 194.24 | 3.23 | 3.23 |
| 344.44 | 2.07 | 2.07 |
| 327.41 | 3.01 | 3.01 |
| 287.34 | 2.60 | 2.60 |
| 304.39 | 4.03 | 4.03 |
| 523.38 | 5.37 | 5.37 |
| 348.48 | 4.08 | 4.08 |
| 441.35 | 4.73 | 4.73 |
| 438.56 | 5.39 | 5.39 |
| 439.54 | 4.78 | 4.78 |
| 428.52 | 4.11 | 4.11 |
| 441.35 | 4.48 | 4.48 |
| 455.38 | 4.87 | 4.87 |
| 469.41 | 5.26 | 5.26 |
| 483.44 | 5.00 | 5.00 |
| 497.46 | 5.39 | 5.39 |
| 461.43 | 5.08 | 5.08 |
| 485.41 | 4.36 | 4.36 |
| 400.10 | 6.58 | 6.58 |
| 382.45 | 3.41 | 3.41 |
| 398.61 | 5.38 | 5.38 |
| 324.36 | 4.43 | 4.43 |
| 292.38 | 4.98 | 4.98 |
| 567.74 | 3.94 | 3.94 |
| 537.24 | 6.39 | 6.39 |
| 436.49 | 3.45 | 3.45 |
| 420.49 | 4.38 | 4.38 |
| 396.43 | 3.60 | 3.60 |
| 318.30 | 5.01 | 5.01 |
| 381.42 | 2.10 | 2.10 |
| 384.39 | 3.73 | 3.73 |
| 609.59 | 6.15 | 6.15 |
| 477.57 | 5.83 | 5.83 |
| 446.51 | 6.31 | 6.31 |
| 425.51 | 3.18 | 3.18 |
| 440.48 | 6.09 | 6.09 |
| 466.34 | 4.83 | 4.83 |
| 476.58 | 7.41 | 7.41 |
| 406.49 | 4.08 | 4.08 |
| 527.65 | 5.03 | 5.03 |
| 515.85 | 6.81 | 6.81 |
| 408.46 | 4.75 | 4.75 |
| 451.96 | 4.38 | 4.38 |
| 357.50 | 4.85 | 4.85 |
| 399.88 | 4.00 | 4.00 |
| 506.56 | 3.85 | 3.85 |
| 453.97 | 6.58 | 6.58 |
| 507.55 | 2.78 | 2.78 |
| 512.01 | 4.40 | 4.40 |
| 445.55 | 4.45 | 4.45 |
| 402.43 | 3.24 | 3.24 |
| 522.56 | 3.43 | 3.43 |
| 506.56 | 3.21 | 3.21 |
| 407.48 | 5.35 | 5.35 |
| 625.66 | 5.56 | 5.56 |
| 393.45 | 5.82 | 5.82 |
| 545.64 | 5.17 | 5.17 |
| 476.36 | 6.87 | 6.87 |
| 387.44 | 5.07 | 5.07 |
| 422.46 | 3.77 | 3.77 |
| 437.90 | 5.86 | 5.86 |
| 441.92 | 6.22 | 6.22 |
| 483.58 | 2.44 | 2.44 |
| 462.52 | 6.66 | 6.66 |
| 396.43 | 3.60 | 3.60 |
| 456.93 | 6.61 | 6.61 |
| 456.93 | 6.61 | 6.61 |
| 462.51 | 3.42 | 3.42 |
| 287.33 | 3.76 | 3.76 |
| 485.57 | 1.25 | 1.25 |
| 451.55 | 3.07 | 3.07 |
| 421.50 | 4.28 | 4.28 |
| 608.61 | 6.76 | 6.76 |
| 494.55 | 3.66 | 3.66 |
| 436.45 | 3.49 | 3.49 |
| 434.48 | 3.96 | 3.96 |
| 466.33 | 6.16 | 6.16 |
| 641.66 | 5.93 | 5.93 |
| 439.52 | 2.86 | 2.86 |
| 343.39 | 4.15 | 4.15 |
| 372.42 | 5.79 | 5.79 |
| 419.51 | 4.29 | 4.29 |
| 587.51 | 7.15 | 7.15 |
| 450.47 | 3.55 | 3.55 |
| 372.43 | 4.67 | 4.67 |
| 424.45 | 4.29 | 4.29 |
| 443.50 | 5.53 | 5.53 |
| 398.51 | 3.08 | 3.08 |
| 562.70 | 6.19 | 6.19 |
| 433.51 | 4.58 | 4.58 |
| 397.44 | 4.93 | 4.93 |
| 453.48 | 5.77 | 5.77 |
| 435.93 | 7.02 | 7.02 |
| 450.54 | 6.57 | 6.57 |
| 436.52 | 6.49 | 6.49 |
| 466.54 | 3.49 | 3.49 |
| 464.50 | 3.15 | 3.15 |
| 336.40 | 5.52 | 5.52 |
| 380.16 | 4.43 | 4.43 |
| 478.53 | 3.02 | 3.02 |
| 370.43 | 1.78 | 1.78 |
| 513.60 | 4.74 | 4.74 |
| 448.53 | 3.32 | 3.32 |
| 508.58 | 3.33 | 3.33 |
| 458.53 | 2.69 | 2.69 |
| 474.52 | 3.13 | 3.13 |
| 500.77 | 6.82 | 6.82 |
| 446.51 | 3.83 | 3.83 |
| 432.48 | 5.43 | 5.43 |
| 415.50 | 3.98 | 3.98 |
| 464.50 | 3.75 | 3.75 |
| 410.43 | 3.90 | 3.90 |
| 524.63 | 5.21 | 5.21 |
| 453.48 | 5.77 | 5.77 |
| 512.04 | 5.90 | 5.90 |
| 452.51 | 5.96 | 5.96 |
| 446.51 | 3.20 | 3.20 |
| 508.54 | 3.38 | 3.38 |
| 452.51 | 5.96 | 5.96 |
| 424.44 | 3.38 | 3.38 |
| 438.92 | 3.81 | 3.81 |
| 556.65 | 3.15 | 3.15 |
| 520.50 | 5.52 | 5.52 |
| 498.79 | 5.82 | 5.82 |
| 318.41 | 4.81 | 4.81 |
| 368.83 | 4.12 | 4.12 |
| 471.49 | 6.88 | 6.88 |
| 427.34 | 4.82 | 4.82 |
| 391.26 | 3.14 | 3.14 |
| 439.92 | 4.51 | 4.51 |
| 448.48 | 3.36 | 3.36 |
| 316.36 | 4.08 | 4.08 |
| 313.36 | 4.75 | 4.75 |
| 521.62 | 5.85 | 5.85 |
| 306.41 | 5.29 | 5.29 |
| 452.54 | 6.37 | 6.37 |
| 471.55 | 4.95 | 4.95 |
| 538.43 | 4.02 | 4.02 |
| 346.35 | 5.83 | 5.83 |
| 500.65 | 7.19 | 7.19 |
| 429.48 | 5.26 | 5.26 |
| 382.53 | 4.32 | 4.32 |
| 383.48 | 5.50 | 5.50 |
| 445.55 | 4.12 | 4.12 |
| 524.93 | 7.63 | 7.63 |
| 467.60 | 3.74 | 3.74 |
| 465.99 | 4.77 | 4.77 |
| 433.94 | 5.71 | 5.71 |
| 478.58 | 3.36 | 3.36 |
| 414.47 | 3.11 | 3.11 |
| 432.53 | 4.25 | 4.25 |
| 519.52 | 6.13 | 6.13 |
| 450.52 | 3.84 | 3.84 |
| 505.60 | 4.47 | 4.47 |
| 389.46 | 6.83 | 6.83 |
| 492.58 | 4.26 | 4.26 |
| 378.35 | 5.02 | 5.02 |
| 508.58 | 3.33 | 3.33 |
| 412.48 | 1.17 | 1.17 |
| 550.54 | 7.18 | 7.18 |
| 337.39 | 4.92 | 4.92 |
| 434.50 | 3.64 | 3.64 |
| 586.52 | 7.75 | 7.75 |
| 430.47 | 4.35 | 4.35 |
| 455.56 | 3.87 | 3.87 |
| 436.49 | 3.45 | 3.45 |
| 478.53 | 3.80 | 3.80 |
| 410.41 | 3.32 | 3.32 |
| 372.42 | 5.79 | 5.79 |
| 447.52 | 2.96 | 2.96 |
| 460.54 | 6.58 | 6.58 |
| 422.49 | 5.95 | 5.95 |
| 570.96 | 7.52 | 7.52 |
| 482.57 | 2.74 | 2.74 |
| 394.45 | 4.21 | 4.21 |
| 407.47 | 4.42 | 4.42 |
| 319.39 | 4.20 | 4.20 |
| 327.39 | 4.45 | 4.45 |
| 312.38 | 4.74 | 4.74 |
| 332.79 | 5.09 | 5.09 |
| 277.33 | 3.29 | 3.29 |
| 313.36 | 4.14 | 4.14 |
| 366.43 | 4.63 | 4.63 |
| 369.45 | 5.35 | 5.35 |
| 353.39 | 4.02 | 4.02 |
| 355.40 | 3.84 | 3.84 |
| 319.39 | 4.20 | 4.20 |
| 493.57 | 4.91 | 4.91 |
| 424.50 | 5.14 | 5.14 |
| 477.57 | 5.93 | 5.93 |
| 371.40 | 0.54 | 0.54 |
| 379.27 | 4.54 | 4.54 |
| 348.40 | 3.49 | 3.49 |
| 344.29 | 3.92 | 3.92 |
| 596.13 | 5.50 | 5.50 |
| 474.97 | 6.04 | 6.04 |
| 474.97 | 6.04 | 6.04 |
| 477.98 | 5.38 | 5.38 |
| 428.42 | ||
| 149.16 | 0.39 | 0.39 |
| 226.24 | 1.18 | 1.18 |
| 225.25 | 1.79 | 1.79 |
| 224.27 | 2.39 | 2.39 |
| 210.24 | 2.21 | 2.21 |
| 320.37 | 4.02 | 4.02 |
| 319.41 | 3.40 | 3.40 |
| 323.40 | 2.56 | 2.56 |
| 428.50 | 3.04 | 3.04 |
| 442.53 | 3.43 | 3.43 |
| 442.53 | 3.43 | 3.43 |
| 456.55 | 3.89 | 3.89 |
| 448.58 | 3.24 | 3.24 |
| 472.55 | 3.27 | 3.27 |
| 464.57 | 2.69 | 2.69 |
| 428.50 | 2.58 | 2.58 |
| 424.51 | 2.68 | 2.68 |
| 240.27 | 1.64 | 1.64 |
| 268.32 | 2.31 | 2.31 |
| 255.28 | 1.23 | 1.23 |
| 283.34 | 2.00 | 2.00 |
| 317.36 | 2.93 | 2.93 |
| 269.31 | 1.25 | 1.25 |
| 295.35 | 1.78 | 1.78 |
| 309.38 | 2.17 | 2.17 |
| 370.42 | 3.07 | 3.07 |
| 596.78 | 6.92 | 6.92 |
| 654.82 | 5.46 | 5.46 |
| 689.27 | 6.65 | 6.65 |
| 649.75 | 6.44 | 6.44 |
| 667.74 | 6.58 | 6.58 |
| 667.74 | 6.58 | 6.58 |
| 378.46 | 3.48 | 3.48 |
| 196.21 | 1.79 | 1.79 |
| 348.45 | 5.12 | 5.12 |
| 312.38 | 1.40 | 1.40 |
| 340.43 | 2.31 | 2.31 |
| 319.34 | 4.21 | 4.21 |
| 304.33 | 3.91 | 3.91 |
| 481.40 | 5.29 | 5.29 |
| 336.40 | 4.32 | 4.32 |
| 513.54 | 4.67 | 4.67 |
| 488.57 | 2.75 | 2.75 |
| 379.25 | 2.69 | 2.69 |
| 360.42 | 2.53 | 2.53 |
| 328.35 | 1.52 | 1.52 |
| 328.35 | 1.52 | 1.52 |
| 344.80 | 2.03 | 2.03 |
| 324.38 | 1.69 | 1.69 |
| 324.38 | 1.69 | 1.69 |
| 378.35 | 2.40 | 2.40 |
| 362.79 | 2.17 | 2.17 |
| 392.38 | 2.71 | 2.71 |
| 393.27 | 3.00 | 3.00 |
| 429.31 | 3.84 | 3.84 |
| 420.44 | 3.32 | 3.32 |
| 442.44 | 3.86 | 3.86 |
| 392.38 | 2.71 | 2.71 |
| 467.61 | 6.04 | 6.04 |
| 394.26 | 2.39 | 2.39 |
| 426.33 | 2.80 | 2.80 |
| 439.46 | 2.83 | 2.83 |
| 421.42 | 2.80 | 2.80 |
| 417.90 | 4.00 | 4.00 |
| 417.90 | 4.00 | 4.00 |
| 413.48 | 3.36 | 3.36 |
| 451.45 | 4.37 | 4.37 |
| 469.44 | 4.51 | 4.51 |
| 437.43 | 3.77 | 3.77 |
| 462.58 | 5.74 | 5.74 |
| 451.56 | 5.07 | 5.07 |
| 385.49 | 4.68 | 4.68 |
| 421.47 | 4.96 | 4.96 |
| 406.39 | 3.88 | 3.88 |
| 401.45 | 3.49 | 3.49 |
| 397.48 | 3.66 | 3.66 |
| 397.48 | 3.66 | 3.66 |
| 421.42 | 2.80 | 2.80 |
| 224.27 | 2.51 | 2.51 |
| 489.35 | 3.94 | 3.94 |
| 435.55 | 3.58 | 3.58 |
| 339.42 | 2.96 | 2.96 |
| 224.27 | 2.51 | 2.51 |
| 510.44 | 4.40 | 4.40 |
| 291.35 | 3.57 | 3.57 |
| 408.29 | 2.78 | 2.78 |