Basic Information
ID: ALA3993219
Type: Binding
Description: Ex vivo positive allosteric modulation of glycine receptor in C57BL/6 mouse spinal cord assessed as potentiation of glycine-induced post synaptic current amplitude at 0.5 uM at holding potential of -60 mV after 10 mins in presence of sodium channel inhibitor TTX/AMPA/kainate receptor antagonist CNQX/GABAa receptor antagonist bicuculline/NMDA receptor antagonist APV by electrophysiology method relative to glycine alone
Organism: Mus musculus
Strain: C57BL/6
Activity Charts
Bioactivity
Activity Types for Assay ALA3993219
FC
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 387.42 | 1.19 | 1.19 |
| 383.43 | 2.21 | 2.21 |
| 387.42 | 1.19 | 1.19 |