Basic Information
ID: ALA3998010
Type: Binding
Description: Activation of PXR in human LS180 cells assessed as P-gp induction by measuring intracellular accumulation of rhodamine 123 per ug of total protein at 5 uM preincubated for 48 hrs followed by rhodamine 123 addition after 40 mins and measured after 90 mins by fluorescence assay relative to control
Format: BAO_0000219
Organism: Homo sapiens
Target: Pregnane X receptor(ALA3401)
Document: ALA3997764
Activation of PXR in human LS180 cells assessed as P-gp induction by measuring intracellular accumulation of rhodamine 123 per ug of total protein at 5 uM preincubated for 48 hrs followed by rhodamine 123 addition after 40 mins and measured after 90 mins by fluorescence assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3998010
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 822.95 | 4.34 | 4.34 |
| 504.54 | 7.82 | 7.82 |
| 560.65 | 9.37 | 9.37 |
| 480.45 | 7.22 | 7.22 |
| 475.50 | 7.14 | 7.14 |
| 483.48 | 7.62 | 7.62 |
| 276.22 | 4.20 | 4.20 |
| 421.32 | 5.43 | 5.43 |
| 238.22 | 3.26 | 3.26 |
| 306.22 | 4.28 | 4.28 |
| 467.39 | 6.57 | 6.57 |
| 411.28 | 5.02 | 5.02 |
| 337.12 | 4.83 | 4.83 |
| 476.44 | 6.80 | 6.80 |
| 353.79 | 5.72 | 5.72 |
| 376.33 | 5.52 | 5.52 |
| 466.40 | 5.54 | 5.54 |
| 436.38 | 5.53 | 5.53 |
| 482.49 | 8.22 | 8.22 |
| 522.51 | 7.10 | 7.10 |
| 274.68 | 4.58 | 4.58 |
| 319.34 | 5.06 | 5.06 |
| 511.33 | 7.83 | 7.83 |
| 476.45 | 7.82 | 7.82 |
| 432.43 | 7.07 | 7.07 |
| 349.16 | 4.69 | 4.69 |
| 306.22 | 4.28 | 4.28 |
| 492.49 | 7.09 | 7.09 |
| 426.39 | 6.67 | 6.67 |