Basic Information
ID: ALA3998013
Type: Binding
Description: Activation of PXR in human LS180 cells assessed as P-gp induction by measuring intracellular accumulation of rhodamine 123 preincubated for 48 hrs followed by rhodamine 123 addition after 40 mins and measured after 90 mins by fluorescence assay
Format: BAO_0000219
Organism: Homo sapiens
Target: Pregnane X receptor(ALA3401)
Document: ALA3997764
Activation of PXR in human LS180 cells assessed as P-gp induction by measuring intracellular accumulation of rhodamine 123 preincubated for 48 hrs followed by rhodamine 123 addition after 40 mins and measured after 90 mins by fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA3998013
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 822.95 | 4.34 | 4.34 |
| 504.54 | 7.82 | 7.82 |
| 376.33 | 5.52 | 5.52 |
| 476.45 | 7.82 | 7.82 |