Basic Information
ID: ALA4003459
Type: Binding
Description: Inhibition of JAK in human PBMC assessed as reduction in human recombinant IL-2/mouse anti-human CD3 stimulated IFNgamma production preincubated for 1 hr followed by IL2/CD3 stimulation measured after 18 hrs by by ELISA
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4003459
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 499.52 | 5.36 | 5.36 |
| 566.64 | 5.01 | 5.01 |
| 356.38 | 4.49 | 4.49 |
| 354.41 | 5.04 | 5.04 |
| 326.36 | 4.48 | 4.48 |
| 373.46 | 3.88 | 3.88 |
| 437.53 | 3.21 | 3.21 |
| 309.37 | 3.20 | 3.20 |
| 295.34 | 2.86 | 2.86 |
| 304.35 | 3.89 | 3.89 |
| 372.40 | 5.18 | 5.18 |
| 368.44 | 5.60 | 5.60 |
| 401.47 | 3.79 | 3.79 |
| 281.31 | 2.60 | 2.60 |
| 467.55 | 5.59 | 5.59 |
| 372.43 | 4.45 | 4.45 |
| 372.40 | 5.18 | 5.18 |
| 368.44 | 5.43 | 5.43 |