Basic Information
ID: ALA4003461
Type: Binding
Description: Inhibition of JAK in human PBMC assessed as reduction in human recombinant IL-2/ mouse anti-human CD3 stimulated STAT5 phosphorylation at tyrosine residue by measuring time taken for inhibition to reverse by 50% at 10-fold IC50 preincubated with cells followed by compound washout and subsequent IL2/CD3 stimulation by immunofluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4003461
T1/2
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 566.64 | 5.01 | 5.01 |
| 354.41 | 5.04 | 5.04 |
| 372.43 | 4.45 | 4.45 |
| 372.40 | 5.18 | 5.18 |