Basic Information
ID: ALA4003504
Type: Binding
Description: Inhibition of JAK in human PBMC assessed as reduction in human recombinant IL-2/ mouse anti-human CD3 stimulated STAT5 phosphorylation at tyrosine residue at 10-fold IC50 preincubated for 1 hr followed by compound washout and subsequent IL2/CD3 stimulation measured after 30 mins by immunofluorescence assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4003504
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 342.45 | 2.32 | 2.32 |
| 498.61 | 2.48 | 2.48 |