Basic Information
ID: ALA4004100
Type: Binding
Description: Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Sodium/glucose cotransporter 2(ALA3884)
Document: ALA4002619
Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4004100
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 274.27 | 2.32 | 2.32 |
| 256.26 | 2.70 | 2.70 |
| 274.25 | 2.84 | 2.84 |
| 335.15 | 3.46 | 3.46 |
| 286.28 | 2.71 | 2.71 |
| 436.41 | -0.20 | -0.20 |
| 408.88 | 1.84 | 1.84 |
| 258.27 | 2.62 | 2.62 |
| 420.41 | 0.13 | 0.13 |
| 270.28 | 3.01 | 3.01 |
| 434.44 | 0.44 | 0.44 |
| 316.35 | 3.41 | 3.41 |
| 362.38 | 4.28 | 4.28 |
| 464.47 | 0.53 | 0.53 |
| 302.33 | 3.02 | 3.02 |
| 438.40 | 0.27 | 0.27 |
| 300.31 | 3.10 | 3.10 |
| 436.41 | -0.16 | -0.16 |
| 272.30 | 2.93 | 2.93 |
| 450.44 | 0.14 | 0.14 |
| 276.26 | 2.76 | 2.76 |
| 478.49 | 0.92 | 0.92 |
| 312.32 | 3.26 | 3.26 |
| 288.30 | 2.63 | 2.63 |