Basic Information
ID: ALA4004648
Type: Binding
Description: Induction of R-state stabilization of Hb betaGlu6Val mutant in sickle disease patient purified HbS/HbA mixture assessed as change from baseline of partial pressure of O2 at which HbS is 50% saturated with O2 at 30 uM preincubated for 45 mins followed by oxygenation for 10 mins and subsequent deoxygenation by hemoximetry relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4004648
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 243.26 | 2.48 | 2.48 |
| 294.31 | 3.03 | 3.03 |
| 352.39 | 3.32 | 3.32 |
| 282.30 | 2.73 | 2.73 |
| 360.37 | 3.42 | 3.42 |
| 388.37 | 3.91 | 3.91 |
| 341.32 | 1.92 | 1.92 |
| 349.35 | 2.52 | 2.52 |
| 352.39 | 3.32 | 3.32 |
| 321.38 | 3.92 | 3.92 |
| 294.31 | 3.03 | 3.03 |
| 362.18 | 2.89 | 2.89 |
| 338.37 | 3.02 | 3.02 |
| 310.31 | 2.06 | 2.06 |
| 324.34 | 2.58 | 2.58 |
| 297.31 | 2.37 | 2.37 |
| 349.35 | 2.52 | 2.52 |
| 310.31 | 2.27 | 2.27 |
| 310.31 | 2.27 | 2.27 |
| 284.27 | 2.62 | 2.62 |
| 396.45 | 3.34 | 3.34 |
| 324.34 | 2.28 | 2.28 |
| 322.37 | 3.31 | 3.31 |
| 283.29 | 2.13 | 2.13 |
| 351.33 | 1.31 | 1.31 |
| 294.31 | 3.03 | 3.03 |
| 338.37 | 2.59 | 2.59 |
| 328.75 | 3.68 | 3.68 |
| 339.37 | 4.06 | 4.06 |
| 338.37 | 3.02 | 3.02 |
| 283.29 | 2.13 | 2.13 |
| 294.31 | 3.03 | 3.03 |
| 324.34 | 2.28 | 2.28 |
| 354.37 | 1.73 | 1.73 |
| 337.38 | 3.62 | 3.62 |
| 298.30 | 1.83 | 1.83 |
| 308.30 | 2.00 | 2.00 |
| 349.35 | 2.52 | 2.52 |
| 310.31 | 2.27 | 2.27 |
| 336.40 | 3.62 | 3.62 |
| 312.29 | 1.06 | 1.06 |
| 295.30 | 2.42 | 2.42 |