Basic Information
ID: ALA4006785
Type: Binding
Description: Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated for 10 mins before substrate addition measured after 8 mins by liquid scintillation counting
Format: BAO_0000019
Organism: Homo sapiens
Target: Farnesyl diphosphate synthase(ALA1782)
Document: ALA4004852
Inhibition of N-terminal His-tagged human recombinant FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [3H]-IPP as substrate preincubated for 10 mins before substrate addition measured after 8 mins by liquid scintillation counting: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4006785
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 269.26 | 2.58 | 2.58 |
| 335.33 | 3.21 | 3.21 |
| 369.77 | 3.87 | 3.87 |
| 445.87 | 5.61 | 5.61 |
| 360.38 | 4.31 | 4.31 |
| 477.89 | 5.62 | 5.62 |
| 461.43 | 5.10 | 5.10 |
| 399.80 | 3.88 | 3.88 |
| 411.42 | 4.96 | 4.96 |
| 489.92 | 5.49 | 5.49 |
| 491.46 | 5.11 | 5.11 |
| 453.46 | 4.89 | 4.89 |
| 425.45 | 4.83 | 4.83 |
| 245.20 | 1.24 | 1.24 |
| 439.48 | 5.13 | 5.13 |
| 403.44 | 4.77 | 4.77 |
| 477.43 | 4.80 | 4.80 |
| 459.90 | 5.48 | 5.48 |
| 475.89 | 5.62 | 5.62 |
| 425.45 | 4.83 | 4.83 |
| 443.44 | 4.96 | 4.96 |
| 383.34 | 3.36 | 3.36 |
| 320.31 | 3.34 | 3.34 |
| 468.48 | 3.90 | 3.90 |
| 473.47 | 4.97 | 4.97 |
| 349.35 | 3.52 | 3.52 |
| 425.45 | 4.83 | 4.83 |
| 431.50 | 5.55 | 5.55 |