Basic Information
ID: ALA4006962
Type: Binding
Description: Inhibition of recombinant human N-terminal truncated GST-tagged DHFR (31 to 395 residues) expressed in Escherichia coli BL21(DE3) pyrD using DHO as substrate preincubated for 5 mins followed by substrate addition measured for 5 mins by DCIP oxidation based CoQ10 enzyme coupled assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Dihydrofolate reductase(ALA202)
Document: ALA4004863
Inhibition of recombinant human N-terminal truncated GST-tagged DHFR (31 to 395 residues) expressed in Escherichia coli BL21(DE3) pyrD using DHO as substrate preincubated for 5 mins followed by substrate addition measured for 5 mins by DCIP oxidation based CoQ10 enzyme coupled assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4006962
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 375.37 | 5.85 | 5.85 |
| 270.21 | 3.00 | 3.00 |
| 353.23 | 3.25 | 3.25 |
| 437.23 | 4.15 | 4.15 |
| 330.29 | 2.72 | 2.72 |
| 366.27 | 3.00 | 3.00 |
| 406.34 | 3.87 | 3.87 |
| 453.30 | 4.62 | 4.62 |
| 379.31 | 3.91 | 3.91 |
| 312.30 | 2.58 | 2.58 |
| 406.34 | 3.87 | 3.87 |
| 366.27 | 3.00 | 3.00 |
| 369.30 | 3.72 | 3.72 |