Basic Information
ID: ALA4009736
Type: Binding
Description: Inhibition of human glutaminyl cyclase assessed as reduction in conversion of H-Gln-AMC hydrobromide to pGlu-AMC preincubated with substrate for 10 mins followed by enzyme addition by pGAPase coupled fluorometry
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4009736
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 334.45 | 2.59 | 2.59 |
| 455.59 | 3.25 | 3.25 |
| 377.51 | 2.18 | 2.18 |
| 433.58 | 2.29 | 2.29 |
| 474.68 | 2.98 | 2.98 |
| 453.61 | 4.17 | 4.17 |
| 455.59 | 2.96 | 2.96 |
| 439.59 | 3.98 | 3.98 |
| 445.63 | 3.83 | 3.83 |
| 431.61 | 3.44 | 3.44 |
| 453.61 | 4.37 | 4.37 |
| 391.54 | 2.52 | 2.52 |
| 469.62 | 3.15 | 3.15 |
| 510.66 | 4.33 | 4.33 |
| 419.60 | 3.30 | 3.30 |
| 419.55 | 2.48 | 2.48 |
| 446.62 | 2.20 | 2.20 |
| 445.63 | 3.74 | 3.74 |
| 454.60 | 3.57 | 3.57 |
| 440.57 | 3.18 | 3.18 |
| 468.63 | 3.96 | 3.96 |
| 454.60 | 3.77 | 3.77 |
| 469.62 | 3.64 | 3.64 |
| 487.61 | 3.78 | 3.78 |
| 425.56 | 3.59 | 3.59 |
| 459.66 | 4.08 | 4.08 |
| 432.59 | 1.86 | 1.86 |
| 441.56 | 2.86 | 2.86 |
| 446.62 | 2.25 | 2.25 |
| 459.66 | 4.13 | 4.13 |
| 377.51 | 2.30 | 2.30 |
| 467.64 | 4.56 | 4.56 |
| 447.61 | 2.68 | 2.68 |
| 473.58 | 3.39 | 3.39 |
| 391.54 | 2.57 | 2.57 |
| 405.57 | 2.96 | 2.96 |
| 431.61 | 3.35 | 3.35 |
| 459.66 | 4.22 | 4.22 |
| 469.62 | 3.35 | 3.35 |
| 445.63 | 3.69 | 3.69 |
| 363.49 | 1.91 | 1.91 |
| 453.61 | 4.37 | 4.37 |
| 483.64 | 3.54 | 3.54 |
| 405.57 | 2.91 | 2.91 |
| 468.63 | 3.96 | 3.96 |
| 460.65 | 2.59 | 2.59 |
| 439.59 | 3.78 | 3.78 |
| 460.65 | 2.64 | 2.64 |
| 461.63 | 3.07 | 3.07 |
| 391.54 | 2.69 | 2.69 |
| 440.57 | 3.38 | 3.38 |
| 473.69 | 4.47 | 4.47 |
| 419.56 | 1.83 | 1.83 |