Inhibition of human glutaminyl cyclase assessed as reduction in conversion of H-Gln-AMC hydrobromide to pGlu-AMC preincubated with substrate for 10 mi...

Basic Information

ID: ALA4009736

Type: Binding

Description: Inhibition of human glutaminyl cyclase assessed as reduction in conversion of H-Gln-AMC hydrobromide to pGlu-AMC preincubated with substrate for 10 mins followed by enzyme addition by pGAPase coupled fluorometry

Format: BAO_0000357

Organism: Homo sapiens

Target: Glutaminyl-peptide cyclotransferase(ALA4508)

Document: ALA4007443

Inhibition of human glutaminyl cyclase assessed as reduction in conversion of H-Gln-AMC hydrobromide to pGlu-AMC preincubated with substrate for 10 mins followed by enzyme addition by pGAPase coupled fluorometry: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4009736

IC50

Total(53)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
334.45	2.59	2.59
455.59	3.25	3.25
377.51	2.18	2.18
433.58	2.29	2.29
474.68	2.98	2.98
453.61	4.17	4.17
455.59	2.96	2.96
439.59	3.98	3.98
445.63	3.83	3.83
431.61	3.44	3.44
453.61	4.37	4.37
391.54	2.52	2.52
469.62	3.15	3.15
510.66	4.33	4.33
419.60	3.30	3.30
419.55	2.48	2.48
446.62	2.20	2.20
445.63	3.74	3.74
454.60	3.57	3.57
440.57	3.18	3.18
468.63	3.96	3.96
454.60	3.77	3.77
469.62	3.64	3.64
487.61	3.78	3.78
425.56	3.59	3.59
459.66	4.08	4.08
432.59	1.86	1.86
441.56	2.86	2.86
446.62	2.25	2.25
459.66	4.13	4.13
377.51	2.30	2.30
467.64	4.56	4.56
447.61	2.68	2.68
473.58	3.39	3.39
391.54	2.57	2.57
405.57	2.96	2.96
431.61	3.35	3.35
459.66	4.22	4.22
469.62	3.35	3.35
445.63	3.69	3.69
363.49	1.91	1.91
453.61	4.37	4.37
483.64	3.54	3.54
405.57	2.91	2.91
468.63	3.96	3.96
460.65	2.59	2.59
439.59	3.78	3.78
460.65	2.64	2.64
461.63	3.07	3.07
391.54	2.69	2.69
440.57	3.38	3.38
473.69	4.47	4.47
419.56	1.83	1.83