Basic Information
ID: ALA4010789
Type: Binding
Description: Inhibition of recombinant TACE catalytic domain (unknown origin) using Abz-LAQAVRSSSR-Dpa as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by FRET assay
Format: BAO_0000357
Organism: Homo sapiens
Target: ADAM17(ALA3706)
Document: ALA4007472
Inhibition of recombinant TACE catalytic domain (unknown origin) using Abz-LAQAVRSSSR-Dpa as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by FRET assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4010789
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 526.66 | 3.39 | 3.39 |
| 526.62 | 2.53 | 2.53 |
| 456.52 | 1.49 | 1.49 |
| 481.57 | 3.58 | 3.58 |
| 498.56 | 1.75 | 1.75 |
| 484.53 | 1.36 | 1.36 |
| 469.56 | 3.46 | 3.46 |
| 497.57 | 2.79 | 2.79 |
| 569.68 | 3.10 | 3.10 |
| 471.54 | 2.19 | 2.19 |
| 485.56 | 2.70 | 2.70 |
| 497.57 | 2.79 | 2.79 |
| 512.59 | 2.14 | 2.14 |
| 512.59 | 2.14 | 2.14 |
| 473.53 | 3.17 | 3.17 |
| 499.59 | 2.78 | 2.78 |
| 514.60 | 1.59 | 1.59 |
| 471.54 | 2.26 | 2.26 |
| 498.56 | 1.75 | 1.75 |
| 483.59 | 3.85 | 3.85 |
| 483.59 | 3.81 | 3.81 |
| 628.58 | 0.87 | 0.87 |
| 455.54 | 3.07 | 3.07 |
| 483.59 | 3.85 | 3.85 |
| 485.56 | 2.65 | 2.65 |
| 469.56 | 3.42 | 3.42 |
| 494.57 | 1.84 | 1.84 |
| 522.63 | 2.62 | 2.62 |
| 495.60 | 3.66 | 3.66 |
| 527.60 | 1.94 | 1.94 |
| 590.72 | 2.72 | 2.72 |
| 469.56 | 3.46 | 3.46 |
| 570.67 | 3.53 | 3.53 |
| 556.64 | 3.14 | 3.14 |
| 481.57 | 3.32 | 3.32 |
| 486.55 | 1.00 | 1.00 |
| 471.54 | 2.31 | 2.31 |
| 569.68 | 3.10 | 3.10 |
| 497.62 | 4.20 | 4.20 |
| 570.67 | 3.53 | 3.53 |
| 469.56 | 3.46 | 3.46 |
| 485.56 | 2.70 | 2.70 |
| 498.56 | 1.75 | 1.75 |
| 541.63 | 2.33 | 2.33 |
| 512.59 | 2.14 | 2.14 |
| 548.64 | 1.51 | 1.51 |
| 457.51 | 1.92 | 1.92 |