Basic Information
ID: ALA4011663
Type: ADME
Description: Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate transport preincubated for 10 mins prior to ATP addition measured after 15 mins in presence of [3H]-taurocholate by topcount based membrane vesicle transport assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4011663
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 383.41 | 1.78 | 1.78 |
| 162.24 | 1.85 | 1.85 |
| 357.79 | 3.93 | 3.93 |
| 331.35 | 1.58 | 1.58 |
| 280.42 | 3.88 | 3.88 |
| 365.84 | 2.08 | 2.08 |
| 303.29 | 1.77 | 1.77 |
| 441.55 | 4.37 | 4.37 |
| 284.75 | 3.15 | 3.15 |
| 267.37 | 1.61 | 1.61 |
| 249.35 | 2.15 | 2.15 |
| 314.86 | 4.53 | 4.53 |
| 222.25 | -0.86 | -0.86 |
| 290.32 | 1.26 | 1.26 |
| 454.61 | 5.09 | 5.09 |
| 398.40 | 3.70 | 3.70 |
| 414.53 | 3.37 | 3.37 |
| 180.16 | 1.31 | 1.31 |
| 259.35 | 2.58 | 2.58 |
| 333.45 | 3.93 | 3.93 |
| 252.35 | 0.60 | 0.60 |
| 330.75 | 1.89 | 1.89 |
| 250.28 | 0.86 | 0.86 |
| 232.24 | 0.70 | 0.70 |
| 309.33 | 4.44 | 4.44 |
| 253.28 | 1.37 | 1.37 |
| 326.83 | 3.72 | 3.72 |
| 263.38 | 3.83 | 3.83 |
| 299.76 | 2.95 | 2.95 |
| 267.31 | 1.67 | 1.67 |
| 250.34 | 3.57 | 3.57 |
| 359.71 | 4.53 | 4.53 |
| 293.37 | 3.13 | 3.13 |
| 302.24 | 1.99 | 1.99 |
| 395.43 | 2.42 | 2.42 |
| 267.33 | 2.85 | 2.85 |
| 375.87 | 4.43 | 4.43 |
| 340.43 | 2.88 | 2.88 |
| 266.30 | 2.65 | 2.65 |
| 137.14 | -0.31 | -0.31 |
| 348.36 | 2.08 | 2.08 |
| 272.37 | 1.09 | 1.09 |
| 494.01 | 3.64 | 3.64 |
| 369.37 | 3.52 | 3.52 |
| 285.34 | 1.20 | 1.20 |
| 318.87 | 4.89 | 4.89 |
| 266.39 | 3.53 | 3.53 |
| 319.88 | 4.81 | 4.81 |
| 358.85 | 4.18 | 4.18 |
| 234.34 | 2.58 | 2.58 |
| 204.23 | 0.83 | 0.83 |
| 327.38 | 1.30 | 1.30 |
| 371.52 | 6.00 | 6.00 |
| 410.49 | 3.59 | 3.59 |
| 299.80 | 2.00 | 2.00 |
| 853.92 | 3.74 | 3.74 |
| 261.09 | 1.88 | 1.88 |
| 276.75 | 1.74 | 1.74 |
| 316.43 | 0.50 | 0.50 |
| 248.33 | 1.91 | 1.91 |
| 198.27 | 2.70 | 2.70 |
| 274.80 | 3.82 | 3.82 |
| 259.35 | 2.78 | 2.78 |
| 314.41 | 1.46 | 1.46 |
| 304.22 | 3.38 | 3.38 |
| 187.20 | 1.02 | 1.02 |
| 339.48 | 3.36 | 3.36 |
| 333.36 | 1.61 | 1.61 |
| 206.28 | 3.07 | 3.07 |
| 281.27 | 2.38 | 2.38 |
| 428.44 | 2.54 | 2.54 |
| 223.30 | 1.94 | 1.94 |
| 399.44 | 2.87 | 2.87 |
| 581.07 | 6.14 | 6.14 |
| 515.10 | 6.48 | 6.48 |
| 242.70 | 3.06 | 3.06 |
| 151.16 | 1.35 | 1.35 |
| 194.19 | -1.03 | -1.03 |
| 179.22 | 2.04 | 2.04 |
| 403.98 | 3.94 | 3.94 |
| 356.42 | 4.37 | 4.37 |
| 670.86 | 3.09 | 3.09 |
| 613.80 | 2.87 | 2.87 |
| 567.80 | 4.75 | 4.75 |
| 505.64 | 2.40 | 2.40 |
| 253.27 | 0.83 | 0.83 |
| 356.45 | 3.16 | 3.16 |
| 357.44 | 2.49 | 2.49 |
| 314.36 | 2.56 | 2.56 |
| 339.39 | 3.86 | 3.86 |
| 371.87 | 2.36 | 2.36 |
| 470.02 | 3.55 | 3.55 |
| 188.23 | 1.48 | 1.48 |
| 278.31 | 0.19 | 0.19 |
| 277.41 | 4.17 | 4.17 |
| 295.41 | 1.32 | 1.32 |
| 392.47 | 1.90 | 1.90 |
| 645.32 | 6.94 | 6.94 |
| 416.53 | 1.38 | 1.38 |
| 277.41 | 3.04 | 3.04 |
| 323.13 | 0.91 | 0.91 |
| 235.33 | 1.34 | 1.34 |
| 284.43 | 4.24 | 4.24 |
| 360.45 | 1.56 | 1.56 |
| 374.48 | 1.80 | 1.80 |
| 325.77 | 4.32 | 4.32 |
| 371.28 | 2.68 | 2.68 |
| 255.36 | 3.35 | 3.35 |
| 287.36 | 1.85 | 1.85 |
| 277.41 | 4.21 | 4.21 |
| 189.22 | 0.16 | 0.16 |
| 360.84 | 4.68 | 4.68 |
| 810.99 | 3.99 | 3.99 |
| 347.46 | 3.60 | 3.60 |
| 387.48 | 0.72 | 0.72 |
| 372.55 | 3.81 | 3.81 |
| 373.95 | 4.58 | 4.58 |
| 628.81 | 4.33 | 4.33 |
| 237.73 | 2.90 | 2.90 |
| 212.23 | 0.62 | 0.62 |
| 608.69 | 4.17 | 4.17 |
| 327.47 | 3.37 | 3.37 |
| 270.35 | 1.78 | 1.78 |
| 454.45 | 0.27 | 0.27 |
| 209.25 | -0.13 | -0.13 |
| 230.26 | 3.04 | 3.04 |
| 276.21 | 3.21 | 3.21 |
| 424.52 | 4.74 | 4.74 |
| 246.31 | -0.28 | -0.28 |
| 323.81 | 3.67 | 3.67 |
| 246.10 | 1.55 | 1.55 |
| 368.52 | 5.11 | 5.11 |
| 153.82 | 2.55 | 2.55 |
| 588.56 | 1.34 | 1.34 |
| 410.56 | 4.34 | 4.34 |
| 495.64 | 5.27 | 5.27 |
| 1202.63 | ||
| 470.33 | 3.20 | 3.20 |
| 480.65 | 4.94 | 4.94 |
| 337.46 | -0.77 | -0.77 |
| 543.53 | 0.00 | 0.00 |
| 720.96 | 5.91 | 5.91 |
| 446.91 | 4.28 | 4.28 |
| 493.62 | 4.59 | 4.59 |
| 551.63 | 4.20 | 4.20 |
| 705.65 | 5.58 | 5.58 |
| 337.38 | 1.64 | 1.64 |
| 514.63 | 7.26 | 7.26 |
| 248.31 | 1.68 | 1.68 |
| 418.57 | 4.59 | 4.59 |
| 268.74 | 1.40 | 1.40 |
| 370.92 | 4.79 | 4.79 |
| 364.42 | 3.04 | 3.04 |
| 445.55 | 2.08 | 2.08 |
| 253.72 | 1.72 | 1.72 |
| 277.37 | 1.72 | 1.72 |
| 179.22 | 0.72 | 0.72 |
| 812.02 | 4.93 | 4.93 |
| 298.43 | 3.49 | 3.49 |
| 609.74 | 6.70 | 6.70 |
| 357.49 | 3.34 | 3.34 |
| 652.83 | 7.45 | 7.45 |
| 473.41 | 7.49 | 7.49 |
| 324.42 | 3.17 | 3.17 |
| 531.44 | 4.21 | 4.21 |
| 324.42 | 3.17 | 3.17 |
| 273.24 | 2.55 | 2.55 |
| 464.83 | 5.55 | 5.55 |
| 205.26 | 0.24 | 0.24 |
| 332.31 | 3.97 | 3.97 |
| 614.65 | -8.90 | -8.90 |
| 484.50 | -7.29 | -7.29 |
| 585.61 | -8.42 | -8.42 |
| 548.63 | 3.48 | 3.48 |
| 407.32 | 2.02 | 2.02 |
| 230.68 | 1.68 | 1.68 |
| 822.95 | 4.34 | 4.34 |
| 418.45 | 2.97 | 2.97 |
| 392.47 | 1.90 | 1.90 |
| 255.23 | -1.97 | -1.97 |
| 225.21 | -1.33 | -1.33 |
| 130.08 | -0.80 | -0.80 |
| 129.17 | -1.03 | -1.03 |
| 1111.34 | ||
| 516.72 | 5.67 | 5.67 |
| 466.54 | 4.35 | 4.35 |
| 444.44 | -0.21 | -0.21 |
| 424.09 | 5.46 | 5.46 |
| 180.17 | -1.04 | -1.04 |
| 847.02 | 4.62 | 4.62 |
| 490.63 | 3.07 | 3.07 |
| 479.53 | 3.68 | 3.68 |
| 304.32 | 2.98 | 2.98 |
| 345.42 | 2.90 | 2.90 |
| 453.46 | -0.54 | -0.54 |
| 277.27 | 1.15 | 1.15 |
| 289.38 | 1.93 | 1.93 |
| 360.37 | 2.57 | 2.57 |
| 253.35 | 3.24 | 3.24 |
| 575.63 | -1.40 | -1.40 |
| 309.41 | 0.63 | 0.63 |
| 289.16 | 3.59 | 3.59 |
| 397.52 | 4.93 | 4.93 |
| 225.29 | 1.52 | 1.52 |
| 223.75 | 2.18 | 2.18 |
| 193.20 | 0.89 | 0.89 |
| 345.85 | 1.90 | 1.90 |
| 185.25 | 3.57 | 3.57 |
| 279.38 | 3.96 | 3.96 |
| 1056.40 | 2.75 | 2.75 |
| 411.47 | 4.63 | 4.63 |
| 1297.30 | ||
| 297.40 | 3.50 | 3.50 |
| 341.50 | 4.26 | 4.26 |
| 436.54 | 3.90 | 3.90 |
| 290.11 | -1.12 | -1.12 |