Basic Information
ID: ALA4011669
Type: ADME
Description: Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell membrane vesicles assessed as reduction in ATP or AMP-dependent [3H]-taurocholic acid uptake in to vesicles preincubated for 5 mins followed by ATP/AMP addition measured after 5 mins by scintillation counting method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4011669
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 303.29 | 1.77 | 1.77 |
| 430.38 | 2.88 | 2.88 |
| 385.51 | 2.09 | 2.09 |
| 494.01 | 3.64 | 3.64 |
| 670.86 | 3.09 | 3.09 |
| 371.87 | 2.36 | 2.36 |
| 470.02 | 3.55 | 3.55 |
| 360.84 | 4.68 | 4.68 |
| 296.15 | 4.36 | 4.36 |
| 241.29 | 3.75 | 3.75 |
| 303.83 | 4.19 | 4.19 |
| 276.21 | 3.21 | 3.21 |
| 381.69 | 5.80 | 5.80 |
| 319.25 | 3.93 | 3.93 |
| 404.49 | 3.80 | 3.80 |
| 477.05 | 5.09 | 5.09 |
| 1202.63 | ||
| 301.39 | 2.96 | 2.96 |
| 551.63 | 4.20 | 4.20 |
| 812.02 | 4.93 | 4.93 |
| 822.95 | 4.34 | 4.34 |
| 418.45 | 2.97 | 2.97 |
| 424.09 | 5.46 | 5.46 |
| 136.11 | 0.06 | 0.06 |
| 697.78 | 4.75 | 4.75 |
| 392.58 | 4.48 | 4.48 |
| 490.63 | 3.07 | 3.07 |
| 346.34 | 2.18 | 2.18 |
| 408.92 | 2.17 | 2.17 |
| 384.52 | 4.43 | 4.43 |
| 427.37 | 3.41 | 3.41 |