Basic Information
ID: ALA4012043
Type: Binding
Description: Antagonist activity at P2X7 receptor in LPS-stimulated human THP1 cells assessed as inhibition of LPS/BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP addition measured after 30 mins by ELISA
Format: BAO_0000019
Organism: Homo sapiens
Target: P2X purinoceptor 7(ALA4805)
Document: ALA4011591
Antagonist activity at P2X7 receptor in LPS-stimulated human THP1 cells assessed as inhibition of LPS/BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP addition measured after 30 mins by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4012043
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 315.38 | 3.83 | 3.83 |
| 323.44 | 2.81 | 2.81 |
| 323.44 | 2.81 | 2.81 |
| 322.46 | 3.42 | 3.42 |
| 340.45 | 3.56 | 3.56 |
| 359.48 | 4.29 | 4.29 |
| 323.44 | 2.81 | 2.81 |