Basic Information
ID: ALA4012044
Type: Binding
Description: Ratio of IC50 for P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced YO-PRO-1 Iodide uptake to IC50 for P2X7 receptor in LPS-stimulated human THP1 cells assessed as inhibition of LPS/BzATP-induced IL-1beta release
Format: BAO_0000219
Organism: Homo sapiens
Target: P2X purinoceptor 7(ALA4805)
Document: ALA4011591
Ratio of IC50 for P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced YO-PRO-1 Iodide uptake to IC50 for P2X7 receptor in LPS-stimulated human THP1 cells assessed as inhibition of LPS/BzATP-induced IL-1beta release: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4012044
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 315.38 | 3.83 | 3.83 |
| 323.44 | 2.81 | 2.81 |
| 323.44 | 2.81 | 2.81 |
| 322.46 | 3.42 | 3.42 |
| 340.45 | 3.56 | 3.56 |
| 359.48 | 4.29 | 4.29 |
| 323.44 | 2.81 | 2.81 |