Basic Information
ID: ALA4012349
Type: ADME
Description: Time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated with enzyme in presence of NADPH followed by substrate addition
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4012349
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 557.51 | 5.20 | 5.20 |
| 567.00 | 5.06 | 5.06 |
| 551.00 | 5.36 | 5.36 |
| 555.53 | 5.78 | 5.78 |
| 541.51 | 5.47 | 5.47 |
| 551.00 | 5.36 | 5.36 |
| 555.53 | 5.78 | 5.78 |
| 523.52 | 5.04 | 5.04 |
| 552.53 | 5.28 | 5.28 |