Basic Information
ID: ALA4012723
Type: Binding
Description: Inhibition of recombinant human NNMT triple mutant expressed in Escherichia coli BL21/DE3 cells using NCA as substrate assessed as decrease in 1-MN formation in presence of SAM, SAH by HPLC-UV method
Format: BAO_0000219
Organism: Homo sapiens
Target: Unchecked(ALA612545)
Document: ALA4011619
Inhibition of recombinant human NNMT triple mutant expressed in Escherichia coli BL21/DE3 cells using NCA as substrate assessed as decrease in 1-MN formation in presence of SAM, SAH by HPLC-UV method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4012723
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 144.20 | 1.66 | 1.66 |
| 144.20 | 1.66 | 1.66 |
| 159.19 | 1.54 | 1.54 |
| 355.85 | 3.04 | 3.04 |
| 160.20 | 1.37 | 1.37 |
| 248.31 | 3.01 | 3.01 |
| 262.33 | 3.32 | 3.32 |
| 203.28 | 2.21 | 2.21 |
| 341.23 | 4.33 | 4.33 |
| 362.21 | 3.41 | 3.41 |
| 220.68 | 2.37 | 2.37 |
| 174.22 | 1.67 | 1.67 |
| 158.22 | 2.15 | 2.15 |
| 346.04 | 2.65 | 2.65 |
| 206.33 | 3.30 | 3.30 |
| 194.26 | 2.82 | 2.82 |
| 194.26 | 2.82 | 2.82 |
| 162.20 | 0.39 | 0.39 |
| 375.29 | 2.99 | 2.99 |
| 307.29 | 1.97 | 1.97 |
| 286.12 | 1.25 | 1.25 |
| 162.22 | 0.49 | 0.49 |
| 240.25 | 3.47 | 3.47 |
| 169.21 | 1.54 | 1.54 |
| 286.12 | 1.25 | 1.25 |
| 188.25 | 1.77 | 1.77 |
| 192.31 | 2.83 | 2.83 |
| 301.13 | 0.83 | 0.83 |
| 307.29 | 1.97 | 1.97 |
| 353.34 | 2.73 | 2.73 |
| 286.12 | 1.25 | 1.25 |
| 202.23 | 1.42 | 1.42 |
| 247.30 | 1.02 | 1.02 |
| 158.22 | 1.97 | 1.97 |
| 350.00 | 2.43 | 2.43 |
| 176.26 | 1.40 | 1.40 |
| 172.25 | 2.46 | 2.46 |
| 165.22 | 0.23 | 0.23 |
| 159.19 | 1.78 | 1.78 |
| 299.16 | 2.28 | 2.28 |
| 190.27 | 1.38 | 1.38 |
| 349.37 | 2.90 | 2.90 |
| 289.09 | 1.80 | 1.80 |
| 304.11 | 1.39 | 1.39 |
| 172.25 | 2.46 | 2.46 |
| 286.12 | 1.25 | 1.25 |
| 286.12 | 1.25 | 1.25 |
| 300.14 | 1.71 | 1.71 |
| 202.23 | 1.42 | 1.42 |
| 190.24 | 2.59 | 2.59 |
| 285.13 | 1.97 | 1.97 |
| 335.35 | 2.59 | 2.59 |
| 286.12 | 1.25 | 1.25 |
| 395.71 | 3.34 | 3.34 |
| 353.34 | 2.73 | 2.73 |
| 350.00 | 2.43 | 2.43 |
| 175.25 | 1.79 | 1.79 |
| 286.12 | 1.25 | 1.25 |
| 286.12 | 1.25 | 1.25 |
| 321.32 | 2.28 | 2.28 |
| 349.37 | 2.90 | 2.90 |
| 158.22 | 1.97 | 1.97 |
| 161.23 | 1.31 | 1.31 |
| 160.20 | 1.37 | 1.37 |
| 307.29 | 1.97 | 1.97 |
| 188.25 | 1.43 | 1.43 |
| 307.29 | 1.97 | 1.97 |
| 382.50 | -0.78 | -0.78 |
| 186.28 | 2.85 | 2.85 |
| 286.12 | 1.25 | 1.25 |
| 349.37 | 2.90 | 2.90 |