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Assay
ALA4012723

Assay Report Card

Basic Information

ID: ALA4012723

Type: Binding

Description: Inhibition of recombinant human NNMT triple mutant expressed in Escherichia coli BL21/DE3 cells using NCA as substrate assessed as decrease in 1-MN formation in presence of SAM, SAH by HPLC-UV method

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4012723

IC50

Total(71)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
144.20	1.66	1.66
144.20	1.66	1.66
159.19	1.54	1.54
355.85	3.04	3.04
160.20	1.37	1.37
248.31	3.01	3.01
262.33	3.32	3.32
203.28	2.21	2.21
341.23	4.33	4.33
362.21	3.41	3.41
220.68	2.37	2.37
174.22	1.67	1.67
158.22	2.15	2.15
346.04	2.65	2.65
206.33	3.30	3.30
194.26	2.82	2.82
194.26	2.82	2.82
162.20	0.39	0.39
375.29	2.99	2.99
307.29	1.97	1.97
286.12	1.25	1.25
162.22	0.49	0.49
240.25	3.47	3.47
169.21	1.54	1.54
286.12	1.25	1.25
188.25	1.77	1.77
192.31	2.83	2.83
301.13	0.83	0.83
307.29	1.97	1.97
353.34	2.73	2.73
286.12	1.25	1.25
202.23	1.42	1.42
247.30	1.02	1.02
158.22	1.97	1.97
350.00	2.43	2.43
176.26	1.40	1.40
172.25	2.46	2.46
165.22	0.23	0.23
159.19	1.78	1.78
299.16	2.28	2.28
190.27	1.38	1.38
349.37	2.90	2.90
289.09	1.80	1.80
304.11	1.39	1.39
172.25	2.46	2.46
286.12	1.25	1.25
286.12	1.25	1.25
300.14	1.71	1.71
202.23	1.42	1.42
190.24	2.59	2.59
285.13	1.97	1.97
335.35	2.59	2.59
286.12	1.25	1.25
395.71	3.34	3.34
353.34	2.73	2.73
350.00	2.43	2.43
175.25	1.79	1.79
286.12	1.25	1.25
286.12	1.25	1.25
321.32	2.28	2.28
349.37	2.90	2.90
158.22	1.97	1.97
161.23	1.31	1.31
160.20	1.37	1.37
307.29	1.97	1.97
188.25	1.43	1.43
307.29	1.97	1.97
382.50	-0.78	-0.78
186.28	2.85	2.85
286.12	1.25	1.25
349.37	2.90	2.90