Basic Information
ID: ALA4013545
Type: Binding
Description: Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in HEK293F cells using histone H4 as substrate preincubated for 15 mins followed by substrate/S-adenosyl methionine addition measured after 60 mins by alpha LISA assay
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4013545
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 343.41 | 3.31 | 3.31 |
| 313.38 | 3.30 | 3.30 |
| 327.41 | 3.61 | 3.61 |
| 319.32 | 4.75 | 4.75 |
| 371.42 | 3.09 | 3.09 |
| 347.83 | 3.96 | 3.96 |
| 323.38 | 3.14 | 3.14 |
| 385.45 | 3.48 | 3.48 |
| 341.39 | 3.08 | 3.08 |
| 359.38 | 3.22 | 3.22 |
| 355.42 | 3.39 | 3.39 |
| 371.42 | 3.09 | 3.09 |
| 399.47 | 3.87 | 3.87 |
| 273.21 | 3.08 | 3.08 |
| 370.43 | 2.66 | 2.66 |
| 325.38 | 3.64 | 3.64 |
| 420.29 | 3.84 | 3.84 |
| 355.42 | 3.50 | 3.50 |
| 375.84 | 3.73 | 3.73 |
| 342.38 | 2.48 | 2.48 |
| 384.46 | 3.15 | 3.15 |
| 384.46 | 3.00 | 3.00 |
| 266.32 | 1.53 | 1.53 |
| 371.42 | 3.09 | 3.09 |
| 356.41 | 2.66 | 2.66 |
| 357.39 | 3.00 | 3.00 |
| 371.42 | 3.09 | 3.09 |
| 357.39 | 2.79 | 2.79 |
| 386.39 | 2.99 | 2.99 |
| 356.45 | 3.37 | 3.37 |
| 372.41 | 2.48 | 2.48 |
| 399.47 | 3.87 | 3.87 |
| 372.41 | 2.48 | 2.48 |
| 385.45 | 3.48 | 3.48 |
| 375.84 | 3.73 | 3.73 |
| 355.42 | 3.39 | 3.39 |
| 370.43 | 3.12 | 3.12 |