Assay Report Card

Basic Information

ID: ALA4015671

Type: Binding

Description: Inhibition of human DNMT3A catalytic domain using AdoMet assessed as reduction of methylation in 5'-biotin/3' 6-carboxyfluorescein labeled DNA duplex at CpG site at 32 uM after 1 hr by fluorescence assay relative to control

Organism: Homo sapiens

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
461.535.655.65
576.756.436.43
611.774.684.68
518.675.995.99
546.726.436.43
545.737.037.03
588.807.107.10
577.695.945.94
510.695.465.46
546.726.436.43
564.716.566.56
567.146.696.69
596.787.587.58
567.146.696.69
546.726.436.43
581.167.087.08
470.625.205.20
518.675.795.79
606.776.446.44
614.727.447.44
510.695.585.58
547.705.785.78
574.777.047.04
574.777.167.16
601.806.466.46
532.696.046.04
546.726.436.43
557.704.044.04
562.726.136.13
548.746.376.37
547.715.625.62
597.777.067.06
578.725.845.84
630.845.615.61
561.735.335.33
496.665.275.27
546.726.436.43
562.726.046.04
560.756.736.73
545.737.037.03
567.146.696.69
614.727.447.44
594.767.667.66
547.715.905.90
428.543.963.96
503.656.526.52
517.633.313.31
546.726.436.43
506.655.695.69
560.756.456.45