Basic Information
ID: ALA4015674
Type: Binding
Description: Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA duplex at 100 uM after 1 hr by scintillation counting method relative to control
Format: BAO_0000357
Organism: Homo sapiens
Target: DNA (cytosine-5)-methyltransferase 1(ALA1993)
Document: ALA4014314
Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA duplex at 100 uM after 1 hr by scintillation counting method relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4015674
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 461.53 | 5.65 | 5.65 |
| 576.75 | 6.43 | 6.43 |
| 611.77 | 4.68 | 4.68 |
| 518.67 | 5.99 | 5.99 |
| 546.72 | 6.43 | 6.43 |
| 545.73 | 7.03 | 7.03 |
| 588.80 | 7.10 | 7.10 |
| 577.69 | 5.94 | 5.94 |
| 510.69 | 5.46 | 5.46 |
| 546.72 | 6.43 | 6.43 |
| 564.71 | 6.56 | 6.56 |
| 567.14 | 6.69 | 6.69 |
| 596.78 | 7.58 | 7.58 |
| 567.14 | 6.69 | 6.69 |
| 546.72 | 6.43 | 6.43 |
| 581.16 | 7.08 | 7.08 |
| 470.62 | 5.20 | 5.20 |
| 518.67 | 5.79 | 5.79 |
| 606.77 | 6.44 | 6.44 |
| 614.72 | 7.44 | 7.44 |
| 510.69 | 5.58 | 5.58 |
| 547.70 | 5.78 | 5.78 |
| 574.77 | 7.04 | 7.04 |
| 574.77 | 7.16 | 7.16 |
| 601.80 | 6.46 | 6.46 |
| 532.69 | 6.04 | 6.04 |
| 546.72 | 6.43 | 6.43 |
| 557.70 | 4.04 | 4.04 |
| 562.72 | 6.13 | 6.13 |
| 548.74 | 6.37 | 6.37 |
| 547.71 | 5.62 | 5.62 |
| 597.77 | 7.06 | 7.06 |
| 578.72 | 5.84 | 5.84 |
| 630.84 | 5.61 | 5.61 |
| 561.73 | 5.33 | 5.33 |
| 496.66 | 5.27 | 5.27 |
| 546.72 | 6.43 | 6.43 |
| 562.72 | 6.04 | 6.04 |
| 560.75 | 6.73 | 6.73 |
| 545.73 | 7.03 | 7.03 |
| 567.14 | 6.69 | 6.69 |
| 614.72 | 7.44 | 7.44 |
| 594.76 | 7.66 | 7.66 |
| 547.71 | 5.90 | 5.90 |
| 428.54 | 3.96 | 3.96 |
| 503.65 | 6.52 | 6.52 |
| 517.63 | 3.31 | 3.31 |
| 546.72 | 6.43 | 6.43 |
| 506.65 | 5.69 | 5.69 |
| 560.75 | 6.45 | 6.45 |