Basic Information
ID: ALA4015695
Type: Binding
Description: Inhibition of recombinant human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins followed by Hoechst 33342 addition measured immediately at 60 sec time interval for 120 mins by fluorescence assay
Format: BAO_0000219
Organism: Homo sapiens
Target: ATP-binding cassette sub-family G member 2(ALA5393)
Document: ALA4014315
Inhibition of recombinant human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins followed by Hoechst 33342 addition measured immediately at 60 sec time interval for 120 mins by fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4015695
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 469.58 | 3.64 | 3.64 |
| 297.36 | 5.04 | 5.04 |
| 313.36 | 4.75 | 4.75 |
| 356.39 | 4.22 | 4.22 |
| 328.38 | 4.44 | 4.44 |
| 356.39 | 4.22 | 4.22 |
| 342.36 | 4.13 | 4.13 |
| 323.36 | 4.31 | 4.31 |
| 396.37 | 5.46 | 5.46 |
| 261.33 | 4.20 | 4.20 |
| 314.35 | 4.14 | 4.14 |
| 292.34 | 3.60 | 3.60 |
| 366.35 | 5.45 | 5.45 |
| 323.36 | 4.31 | 4.31 |
| 328.38 | 3.93 | 3.93 |
| 286.34 | 4.07 | 4.07 |
| 358.36 | 4.65 | 4.65 |
| 328.38 | 4.44 | 4.44 |
| 343.35 | 4.34 | 4.34 |
| 366.35 | 5.45 | 5.45 |
| 314.35 | 4.14 | 4.14 |
| 342.36 | 4.13 | 4.13 |
| 380.40 | 4.09 | 4.09 |
| 343.35 | 4.34 | 4.34 |
| 292.34 | 3.60 | 3.60 |
| 323.36 | 4.31 | 4.31 |
| 343.35 | 4.34 | 4.34 |
| 358.40 | 4.45 | 4.45 |
| 358.40 | 4.45 | 4.45 |
| 287.33 | 3.46 | 3.46 |
| 359.35 | 4.05 | 4.05 |
| 328.38 | 3.93 | 3.93 |
| 315.35 | 5.18 | 5.18 |
| 322.37 | 4.91 | 4.91 |
| 322.32 | 3.81 | 3.81 |
| 323.36 | 4.31 | 4.31 |
| 328.38 | 4.44 | 4.44 |
| 286.34 | 4.07 | 4.07 |
| 341.42 | 4.50 | 4.50 |
| 316.34 | 4.57 | 4.57 |
| 328.38 | 4.44 | 4.44 |
| 343.35 | 4.34 | 4.34 |
| 398.47 | 5.39 | 5.39 |
| 358.40 | 4.45 | 4.45 |