Basic Information
ID: ALA4017369
Type: Binding
Description: Inhibition of human N-terminal GST-tagged MLL1 (3735 to 3973 residues) interaction with human full length N-terminal 6xHis-tagged ASH2L/N-terminal 6xHis-tagged human full length RbBP5/human N-terminal 6xHis-tagged WDR5/human full length N-terminal 6xHis-tagged DPY30 assessed as decrease in H3K4me1-2 methylation preincubated for 30 mins followed by SAM/nucleosome mixture addition measured after 120 mins in absence of light by AlphaLISA assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4017369
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 633.84 | 3.40 | 3.40 |
| 714.79 | 0.66 | 0.66 |
| 728.81 | 0.63 | 0.63 |
| 742.84 | 1.36 | 1.36 |
| 672.71 | -0.46 | -0.46 |
| 658.68 | -0.85 | -0.85 |
| 770.89 | 2.14 | 2.14 |
| 672.71 | -0.46 | -0.46 |
| 714.79 | 0.58 | 0.58 |
| 586.74 | 0.32 | 0.32 |
| 686.73 | -0.20 | -0.20 |
| 732.78 | 0.80 | 0.80 |
| 686.73 | -0.07 | -0.07 |
| 714.79 | 0.71 | 0.71 |
| 700.76 | 0.32 | 0.32 |
| 686.73 | -0.07 | -0.07 |
| 749.23 | 1.31 | 1.31 |
| 644.65 | -1.24 | -1.24 |
| 686.73 | -0.20 | -0.20 |