Assay Report Card

Basic Information

ID: ALA4017550

Type: ADME

Description: Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-taurocholate transport into vesicles incubated for 5 mins by Topcount based rapid filtration method

Organism: Homo sapiens

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
383.411.781.78
162.241.851.85
361.371.541.54
357.793.933.93
331.351.581.58
264.373.083.08
365.842.082.08
303.291.771.77
441.554.374.37
914.196.186.18
314.864.534.53
155.200.420.42
305.160.290.29
231.091.811.81
290.321.261.26
146.141.791.79
407.514.954.95
341.430.560.56
307.432.392.39
259.352.582.58
266.341.381.38
334.400.860.86
252.350.600.60
328.412.142.14
401.442.372.37
389.390.970.97
211.261.131.13
330.751.891.89
248.722.522.52
357.353.563.56
264.311.171.17
250.280.860.86
614.65-8.90-8.90
300.445.605.60
309.334.444.44
253.281.371.37
326.833.723.72
278.341.481.48
399.975.975.97
267.311.671.67
214.250.090.09
401.491.221.22
385.512.092.09
211.220.440.44
267.332.852.85
375.874.434.43
340.432.882.88
194.190.080.08
194.190.080.08
266.302.652.65
498.534.124.12
153.180.600.60
395.483.223.22
232.241.661.66
137.14-0.31-0.31
258.230.090.09
408.463.743.74
494.013.643.64
441.581.981.98
182.190.070.07
370.595.895.89
318.874.894.89
266.393.533.53
232.281.351.35
382.465.495.49
351.411.561.56
327.381.301.30
371.526.006.00
410.493.593.59
468.372.112.11
276.751.741.74
160.180.920.92
111.15-0.09-0.09
416.136.456.45
236.302.732.73
198.272.702.70
379.504.364.36
275.351.771.77
135.171.651.65
259.352.782.78
296.154.744.74
285.392.662.66
314.411.461.46
214.051.161.16
187.201.021.02
206.283.073.07
211.261.081.08
286.331.751.75
314.474.724.72
309.434.014.01
398.483.333.33
124.141.401.40
344.855.385.38
262.23-0.20-0.20
265.351.991.99
352.473.253.25
223.301.941.94
399.442.872.87
393.443.413.41
581.076.146.14
409.424.794.79
236.273.393.39
294.403.163.16
354.452.652.65
144.212.292.29
359.402.322.32
463.805.945.94
238.332.852.85
244.263.683.68
151.161.351.35
194.19-1.03-1.03
403.983.943.94
356.424.374.37
297.144.414.41
228.343.103.10
236.311.771.77
352.435.265.26
238.160.070.07
165.191.451.45
348.401.131.13
279.342.552.55
305.762.732.73
471.696.456.45
470.525.005.00
356.453.163.16
357.442.492.49
281.362.842.84
77.15-0.13-0.13
341.411.531.53
314.362.562.56
339.393.863.86
403.534.064.06
337.303.173.17
516.869.919.91
194.19-0.18-0.18
337.351.121.12
470.023.553.55
201.252.692.69
356.493.663.66
188.231.481.48
341.453.243.24
645.326.946.94
277.413.043.04
323.130.910.91
360.451.561.56
374.481.801.80
414.353.443.44
371.282.682.68
146.210.260.26
263.384.304.30
275.404.554.55
189.220.160.16
159.231.751.75
244.292.672.67
355.875.185.18
296.154.364.36
296.413.613.61
141.170.450.45
264.372.622.62
517.56-0.24-0.24
153.140.670.67
347.463.603.60
387.480.720.72
239.311.311.31
312.443.443.44
353.514.664.66
137.140.490.49
437.534.314.31
373.954.584.58
404.505.395.39
268.362.222.22
234.202.782.78
397.383.273.27
371.352.482.48
167.210.640.64
210.282.382.38
198.310.740.74
160.221.231.23
102.09-1.62-1.62
299.35-0.18-0.18
608.694.174.17
211.261.131.13
167.210.640.64
270.351.781.78
303.362.062.06
189.211.161.16
454.450.270.27
190.21-0.96-0.96
230.263.043.04
276.213.213.21
179.312.692.69
381.695.805.80
338.743.363.36
306.245.185.18
142.16-0.91-0.91
317.233.843.84
261.120.570.57
311.411.771.77
246.31-0.28-0.28
326.474.444.44
361.833.553.55
298.454.494.49
263.793.963.96
292.381.701.70
220.281.371.37
302.333.033.03
305.211.931.93
278.403.923.92
220.343.213.21
458.585.355.35
218.261.471.47
290.793.403.40
375.214.824.82
206.03-0.99-0.99
1202.63
274.18
435.892.552.55
470.333.203.20
239.753.303.30
374.913.063.06
285.372.202.20
269.393.663.66
315.875.195.19
178.190.420.42
404.345.505.50
301.392.962.96
226.282.642.64
171.241.371.37
493.624.594.59
361.404.114.11
229.63-1.08-1.08
305.423.793.79
200.280.820.82
551.634.204.20
270.213.253.25
310.340.880.88
149.281.541.54
296.553.623.62
147.20-0.21-0.21
312.412.532.53
198.220.430.43
262.352.212.21
136.201.711.71
239.311.311.31
237.25-1.10-1.10
270.382.922.92
354.454.614.61
366.554.834.83
244.383.153.15
277.505.305.30
434.472.252.25
356.513.623.62
425.893.213.21
248.311.681.68
464.612.902.90
145.161.941.94
307.424.954.95
418.574.594.59
435.534.164.16
396.953.153.15
369.420.950.95
364.423.043.04
365.410.020.02
343.473.493.49
136.200.690.69
253.312.952.95
238.240.960.96
204.231.301.30
277.371.721.72
179.220.720.72
129.110.030.03
379.443.683.68
313.793.433.43
118.16-0.22-0.22
313.421.131.13
362.09
346.825.015.01
309.494.404.40
296.20-0.80-0.80
478.642.882.88
465.602.022.02
348.432.532.53
299.413.433.43
245.332.352.35
298.433.493.49
355.442.902.90
138.170.400.40
133.191.501.50
436.275.495.49
154.191.671.67
270.341.231.23
430.382.882.88
414.533.373.37
467.653.243.24
235.332.622.62
272.393.523.52
308.422.952.95
306.453.723.72
443.643.473.47
193.252.232.23
366.484.494.49
348.494.354.35
312.485.025.02
776.372.852.85
648.251.121.12
301.734.344.34
259.352.572.57
205.261.281.28
206.332.792.79
449.572.872.87
448.404.734.73
392.503.413.41
372.813.143.14
491.075.095.09
249.273.603.60
170.21-0.13-0.13
536.8912.6112.61
258.232.312.31
531.444.214.21
324.423.173.17
362.412.422.42
265.362.692.69
244.292.292.29
318.382.462.46
273.242.552.55
464.835.555.55
311.433.703.70
205.260.240.24
175.240.940.94
161.20-1.81-1.81
294.31-0.31-0.31
316.430.500.50
416.473.093.09
169.180.080.08
352.502.172.17
387.483.743.74
483.573.583.58
615.63-8.86-8.86
288.392.582.58
270.373.823.82
323.421.631.63
336.174.404.40
344.414.874.87
364.835.215.21
398.385.585.58
137.160.320.32
488.023.313.31
407.322.022.02
461.565.865.86
230.681.681.68
397.432.902.90
392.471.901.90
225.21-1.33-1.33
488.402.912.91
461.541.101.10
339.37-0.40-0.40
130.08-0.80-0.80
129.17-1.03-1.03
184.264.054.05
453.882.692.69
584.66-1.51-1.51
169.180.090.09
179.612.592.59
166.251.281.28
362.471.781.78
285.312.662.66
135.13-0.11-0.11
182.220.730.73
204.302.152.15
210.280.070.07
413.861.861.86
308.333.613.61
336.302.902.90
343.322.412.41
401.983.693.69
228.253.463.46
337.464.224.22
490.633.073.07
161.220.180.18
479.533.683.68
266.691.291.29
422.924.274.27
474.591.611.61
408.882.272.27
376.144.564.56
413.432.882.88
281.403.893.89
156.612.662.66
330.473.703.70
360.451.991.99
764.953.253.25
346.342.182.18
371.392.582.58
114.170.710.71
370.482.532.53
133.191.501.50
310.340.880.88
453.46-0.54-0.54
277.271.151.15
392.584.484.48
286.28-1.64-1.64
289.381.931.93
361.440.380.38
89.090.100.10
168.582.062.06
789.10-0.03-0.03
408.922.172.17
438.522.572.57
219.24-1.04-1.04
470.463.633.63
309.410.630.63
237.251.831.83
441.40-0.04-0.04
444.44-0.21-0.21
450.719.169.16
353.471.941.94
356.423.173.17
344.31-5.76-5.76
366.472.902.90
320.055.935.93
473.45-0.73-0.73
421.421.631.63
186.241.561.56
385.382.462.46
247.303.083.08
365.833.333.33
420.352.702.70
405.242.202.20
437.583.353.35
287.371.801.80
341.39-0.48-0.48
303.360.920.92
780.952.222.22
254.25-2.21-2.21
331.300.010.01
328.484.504.50
319.453.883.88
209.250.170.17
376.472.782.78
409.625.805.80
172.251.351.35
414.344.874.87
249.272.532.53
274.413.513.51
257.25-1.76-1.76
227.742.762.76
270.762.422.42
243.331.661.66
303.360.920.92
484.664.674.67
301.392.872.87
243.173.053.05
404.423.073.07
469.97
326.617.807.80
1334.98
376.472.922.92
284.362.212.21
1736.18
203.282.922.92
297.833.153.15
798.854.564.56
503.092.392.39
454.973.893.89
367.832.082.08
205.25-1.14-1.14
436.522.502.50
431.952.242.24
241.240.530.53
672.963.953.95
338.443.723.72
384.524.584.58
307.444.424.42
239.311.911.91
289.423.923.92
226.23-0.05-0.05
668.72-8.03-8.03
314.261.741.74
167.210.770.77
410.461.841.84
395.293.713.71
361.743.343.34
343.292.402.40
356.332.732.73
398.372.672.67
478.883.133.13
456.324.254.25
377.493.613.61
383.402.872.87
263.04
172.09-0.21-0.21
142.180.740.74
275.09
289.371.931.93
336.74
603.752.832.83
458.553.923.92
261.392.712.71
325.362.092.09
234.263.113.11
211.130.600.60
284.731.511.51
200.581.351.35
276.383.483.48
355.401.751.75
257.252.342.34
381.446.196.19
264.282.212.21
420.512.022.02
424.502.572.57
364.421.091.09
275.351.891.89
383.534.454.45
281.311.181.18
372.803.403.40
193.201.271.27
392.522.352.35
410.625.175.17
253.713.093.09
539.642.932.93
654.841.891.89
286.333.323.32
338.410.830.83
302.374.094.09
538.705.675.67
362.361.461.46
302.352.372.37
448.424.874.87
344.282.252.25
390.953.413.41
405.976.566.56
1017.649.009.00
363.390.150.15
394.440.620.62
1297.30
239.04
822.954.344.34
847.024.624.62
167.302.422.42
207.253.473.47
368.513.433.43
412.523.853.85
262.262.322.32
516.644.324.32
458.593.543.54
733.941.791.79
561.687.657.65
404.512.832.83
451.521.311.31
324.164.604.60
685.70-8.67-8.67
412.832.682.68
130.14-0.07-0.07
456.364.654.65
450.544.964.96
464.545.615.61
363.444.114.11
453.951.431.43
431.963.293.29
265.323.623.62
349.410.350.35
208.261.161.16
382.823.573.57
454.940.830.83
563.676.126.12
216.282.942.94
327.194.154.15
444.563.293.29
384.522.362.36
445.993.683.68
330.350.110.11
787.1412.3612.36
749.001.901.90
468.971.221.22
366.204.414.41
532.646.156.15
409.391.031.03
452.962.042.04
243.291.331.33
434.502.322.32
519.614.964.96
397.202.242.24
581.58-7.74-7.74
408.934.564.56
398.593.843.84
306.312.202.20
311.433.813.81
455.522.892.89
510.585.475.47
444.562.982.98
246.352.732.73
428.535.175.17
747.962.442.44
326.204.764.76
354.164.544.54
480.984.034.03
435.522.132.13
402.534.074.07
447.521.021.02
483.981.941.94
386.933.743.74
466.872.832.83
321.384.164.16
452.997.147.14
378.214.624.62
294.32-1.53-1.53
191.250.140.14
375.523.803.80
369.734.774.77
383.792.492.49
471.52-0.79-0.79
399.471.581.58
487.956.316.31
435.522.032.03
294.353.203.20
442.35
468.962.152.15
394.254.464.46
338.462.402.40
453.951.431.43
740.761.541.54