Assay Report Card

Basic Information

ID: ALA4019567

Type: Binding

Description: Inhibition of P-gp in human HCT116/VM46 cells assessed as ratio of IC50 for resistant cells to IC50 for wild type cells after 72 hrs by phosphatase assay

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA4019567

Ratio IC50

Total(180)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
810.99	3.99	3.99
828.98	4.13	4.13
905.06	4.42	4.42
1071.90
928.14	5.74	5.74
944.14	5.44	5.44
965.16	5.98	5.98
878.08	4.52	4.52
930.11	5.42	5.42
998.11	6.33	6.33
980.19	4.99	4.99
1013.03
918.10	4.16	4.16
1004.19
935.18	4.46	4.46
936.20	6.48	6.48
1048.29
905.06	4.42	4.42
948.56	6.08	6.08
974.23	6.54	6.54
954.13	6.17	6.17
982.11	6.45	6.45
995.16	4.89	4.89
955.12	5.57	5.57
948.56	6.08	6.08
954.13	6.17	6.17
866.07	4.52	4.52
928.14	5.74	5.74
1043.27
998.11	6.33	6.33
996.17	5.09	5.09
932.10	5.57	5.57
929.13	5.01	5.01
964.17	6.58	6.58
954.18	5.53	5.53
920.14	5.49	5.49
1043.27
970.18	5.75	5.75
941.14	5.22	5.22
965.16	5.98	5.98
916.09	4.22	4.22
1006.21
950.17	4.98	4.98
958.17	5.75	5.75
970.20	6.64	6.64
1055.28
943.15	4.89	4.89
972.19	6.05	6.05
921.15	4.11	4.11
1043.27
892.11	4.91	4.91
906.13	5.31	5.31
1000.23
986.19	6.45	6.45
970.22	6.94	6.94
979.19	6.16	6.16
1043.30
955.12	5.57	5.57
943.15	5.32	5.32
932.10	5.57	5.57
956.19	6.38	6.38
985.19	5.70	5.70
915.10	4.82	4.82
994.20	6.59	6.59
964.17	6.58	6.58
982.23	6.70	6.70
1016.10
956.19	6.55	6.55
992.25	5.90	5.90
921.13	4.89	4.89
968.20	5.92	5.92
915.10	4.82	4.82
970.20	6.64	6.64
988.26	6.93	6.93
990.21	7.10	7.10
987.16	5.61	5.61
968.16	5.32	5.32
1004.24
942.17	6.05	6.05
992.61	6.48	6.48
864.05	4.30	4.30
940.15	5.83	5.83
1028.13
930.11	5.42	5.42
965.16	5.98	5.98
894.12	5.16	5.16
959.11	5.34	5.34
905.06	4.42	4.42
985.19	5.26	5.26
954.18	5.92	5.92
944.14	5.44	5.44
943.15	5.32	5.32
965.16	5.98	5.98
974.16	5.45	5.45
928.14	5.36	5.36
970.22	6.77	6.77
994.20	6.59	6.59
971.19	6.04	6.04
993.01	6.19	6.19
966.15	5.37	5.37
916.09	4.22	4.22
1028.13
960.21	6.15	6.15
982.11	6.45	6.45
1007.22
955.12	5.57	5.57
948.56	6.08	6.08
970.22	6.55	6.55
972.19	6.22	6.22
978.58	6.09	6.09
954.13	6.17	6.17
999.22	5.27	5.27
939.12	5.30	5.30
928.14	5.74	5.74
998.11	6.33	6.33
942.17	6.05	6.05
941.14	5.22	5.22
904.07	5.02	5.02
1020.24
971.16	5.39	5.39
920.14	5.49	5.49
995.16	4.89	4.89
965.16	5.98	5.98
958.12	5.16	5.16
918.10	4.16	4.16
958.17	5.83	5.83
992.15	5.58	5.58
1021.27
908.15	5.70	5.70
970.20	6.64	6.64
955.17	5.40	5.40
968.20	6.31	6.31
983.00	6.74	6.74
954.13	6.17	6.17
957.18	5.49	5.49
942.17	5.99	5.99
920.16	5.70	5.70
970.22	6.73	6.73
971.19	6.04	6.04
1037.06
932.10	5.57	5.57
956.19	6.55	6.55
962.13	5.58	5.58
956.15	5.36	5.36
996.26	7.48	7.48
915.10	4.82	4.82
941.14	5.22	5.22
986.22	6.61	6.61
1029.24
964.19	5.29	5.29
1023.03
921.13	4.89	4.89
1043.27
938.20	5.26	5.26
946.18	5.89	5.89
958.17	5.75	5.75
880.10	4.77	4.77
972.15	5.20	5.20
1024.31
904.07	5.02	5.02
1079.30
1014.23
944.14	5.44	5.44
914.11	5.43	5.43
970.22	6.63	6.63
1002.22
971.19	6.04	6.04
993.01	6.19	6.19
996.17	5.09	5.09
966.15	5.37	5.37
982.11	6.45	6.45
970.20	6.64	6.64
960.21	6.15	6.15
1047.26
980.12	6.03	6.03
943.15	5.47	5.47
922.13	4.54	4.54
962.13	5.58	5.58
965.16	5.98	5.98
953.15	5.61	5.61