Basic Information
ID: ALA4019814
Type: Functional
Description: Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-induced calcium flux preincubated for 10 mins followed by glutamate addition measured for 3 mins by Fluo4-AM dye based fluorescence assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Metabotropic glutamate receptor 4(ALA2736)
Document: ALA4017520
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-induced calcium flux preincubated for 10 mins followed by glutamate addition measured for 3 mins by Fluo4-AM dye based fluorescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4019814
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 294.31 | 2.65 | 2.65 |
| 289.29 | 3.33 | 3.33 |
| 288.31 | 3.94 | 3.94 |
| 470.56 | 4.87 | 4.87 |
| 447.54 | 3.44 | 3.44 |
| 351.36 | 3.06 | 3.06 |
| 423.49 | 3.71 | 3.71 |
| 362.39 | 3.96 | 3.96 |
| 276.30 | 3.87 | 3.87 |
| 302.33 | 4.25 | 4.25 |
| 277.28 | 3.27 | 3.27 |
| 490.63 | 4.94 | 4.94 |
| 406.44 | 2.75 | 2.75 |
| 287.32 | 4.54 | 4.54 |
| 291.31 | 3.28 | 3.28 |
| 273.29 | 4.01 | 4.01 |
| 482.61 | 6.16 | 6.16 |
| 289.29 | 3.33 | 3.33 |
| 390.44 | 3.51 | 3.51 |
| 412.45 | 4.44 | 4.44 |
| 443.55 | 3.99 | 3.99 |
| 318.33 | 3.95 | 3.95 |
| 372.30 | 4.84 | 4.84 |
| 289.29 | 3.33 | 3.33 |
| 294.33 | 4.00 | 4.00 |
| 302.33 | 4.25 | 4.25 |
| 407.45 | 3.61 | 3.61 |
| 288.31 | 3.94 | 3.94 |
| 455.53 | 5.66 | 5.66 |
| 288.31 | 3.94 | 3.94 |
| 418.45 | 3.43 | 3.43 |
| 392.46 | 5.72 | 5.72 |
| 457.50 | 5.11 | 5.11 |
| 328.37 | 4.82 | 4.82 |
| 318.33 | 3.95 | 3.95 |
| 290.32 | 3.88 | 3.88 |
| 277.28 | 4.14 | 4.14 |
| 356.30 | 4.96 | 4.96 |
| 421.52 | 4.26 | 4.26 |
| 277.28 | 3.04 | 3.04 |
| 457.52 | 4.45 | 4.45 |
| 426.48 | 4.75 | 4.75 |
| 430.51 | 3.56 | 3.56 |
| 277.28 | 3.04 | 3.04 |
| 263.30 | 3.89 | 3.89 |
| 367.20 | 4.70 | 4.70 |
| 305.34 | 3.65 | 3.65 |
| 294.33 | 4.00 | 4.00 |
| 442.50 | 4.66 | 4.66 |
| 277.28 | 3.04 | 3.04 |
| 419.49 | 2.66 | 2.66 |
| 440.45 | 4.15 | 4.15 |
| 441.50 | 5.27 | 5.27 |
| 419.44 | 2.78 | 2.78 |
| 362.39 | 3.96 | 3.96 |
| 322.75 | 4.59 | 4.59 |
| 288.31 | 3.94 | 3.94 |
| 367.20 | 4.70 | 4.70 |
| 302.33 | 4.11 | 4.11 |
| 449.53 | 4.64 | 4.64 |
| 293.35 | 4.60 | 4.60 |