Basic Information
ID: ALA4020219
Type: ADME
Description: Unbound intrinsic clearance in human liver microsomes at 10 uM preincubated for 5 mins followed by NADPH addition measured after 60 mins by HPLC-UV-MS analysis
Format: BAO_0000019
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: microsome
Target: Liver(ALA613419)
Document: ALA4017535
Unbound intrinsic clearance in human liver microsomes at 10 uM preincubated for 5 mins followed by NADPH addition measured after 60 mins by HPLC-UV-MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4020219
CL
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 271.40 | 3.38 | 3.38 |
| 410.46 | 3.09 | 3.09 |
| 438.51 | 3.54 | 3.54 |
| 423.49 | 4.09 | 4.09 |
| 461.90 | 4.49 | 4.49 |
| 477.46 | 4.63 | 4.63 |
| 451.50 | 3.86 | 3.86 |
| 359.39 | 3.42 | 3.42 |
| 387.44 | 4.08 | 4.08 |
| 417.49 | 2.46 | 2.46 |
| 373.41 | 4.28 | 4.28 |
| 477.46 | 4.50 | 4.50 |
| 448.50 | 3.96 | 3.96 |
| 410.46 | 3.09 | 3.09 |
| 415.52 | 3.62 | 3.62 |
| 417.53 | 3.72 | 3.72 |
| 423.49 | 3.48 | 3.48 |
| 425.47 | 2.88 | 2.88 |
| 409.47 | 3.70 | 3.70 |
| 394.45 | 3.73 | 3.73 |
| 445.45 | 3.98 | 3.98 |
| 395.44 | 2.97 | 2.97 |
| 316.36 | 4.33 | 4.33 |
| 459.47 | 4.37 | 4.37 |
| 491.49 | 5.11 | 5.11 |
| 477.46 | 4.72 | 4.72 |
| 472.61 | 3.55 | 3.55 |
| 444.56 | 2.77 | 2.77 |
| 457.94 | 4.74 | 4.74 |