Basic Information
ID: ALA4020861
Type: Binding
Description: Inhibition of FUT8 in human Hep5-positive cells at 100 uM using (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-((2R,3R,4R,5S,6R)-3-acetamido-5-((2S,3R,4R,5S,6R)-3-acetamido-5-((2S,3S,4S,5R,6R)-4-((2R,3S,4S,5S,6R)-3-((2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-6-(((2S,3S,4S,5S,6R)-3-((2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)methyl)-3,5-dihydroxytetrahydro-2H-pyran-2-yloxy)-4-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-ylamino)-4-oxobutanoic acid as substrate after 24 hrs in presence of GDP-fucose by HPLC method relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4020861
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 576.70 | -0.02 | -0.02 |
| 573.67 | -0.82 | -0.82 |
| 518.55 | -2.45 | -2.45 |
| 559.65 | -1.17 | -1.17 |
| 528.55 | -2.31 | -2.31 |
| 532.58 | -1.52 | -1.52 |