Basic Information
ID: ALA4022895
Type: Binding
Description: Corrector activity at HRP-fused CFTR F508del mutant (unknown origin) expressed in human CFBE41o cells assessed as increase in matured protein levels at cell surface after 18 to 24 hrs by luminescence assay relative to 3-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]-carbonyl}amino)-7-methoxy-3,4-dihydro-2H-chromen-2-yl]benzoic acid
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4022895
max activation
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 483.90 | 6.07 | 6.07 |
| 539.53 | 5.45 | 5.45 |
| 449.45 | 5.42 | 5.42 |
| 479.48 | 5.43 | 5.43 |
| 483.90 | 6.07 | 6.07 |
| 453.84 | 5.25 | 5.25 |
| 523.49 | 5.13 | 5.13 |
| 467.44 | 5.56 | 5.56 |
| 419.40 | 4.60 | 4.60 |
| 539.53 | 5.45 | 5.45 |
| 455.38 | 4.50 | 4.50 |
| 479.48 | 4.91 | 4.91 |
| 539.53 | 5.45 | 5.45 |
| 419.40 | 4.60 | 4.60 |
| 483.90 | 6.07 | 6.07 |