Basic Information
ID: ALA4023997
Type: Binding
Description: Inhibition of fluorescent-labeled 3-(3-((3-(4-amino-5-(4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)amino)-3-oxopropyl)-5,5-difluoro-7,9-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f]-[1,3,2]diazaborinin-4-ium-5-uide binding to human N-terminal GST/His-tagged RIPK1 (1 to 375 residues) expressed in baculovirus expression system assessed as dissociation half life by TR-FRET assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4023997
T1/2
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 431.35 | 5.27 | 5.27 |
| 380.45 | 2.11 | 2.11 |
| 461.91 | 2.88 | 2.88 |
| 402.45 | 2.35 | 2.35 |
| 416.48 | 2.66 | 2.66 |
| 402.45 | 2.35 | 2.35 |
| 493.95 | 2.37 | 2.37 |
| 420.44 | 2.49 | 2.49 |
| 377.40 | 1.55 | 1.55 |
| 507.98 | 2.71 | 2.71 |
| 463.44 | 2.50 | 2.50 |
| 436.90 | 3.01 | 3.01 |
| 403.44 | 1.75 | 1.75 |
| 444.51 | 0.74 | 0.74 |
| 438.43 | 2.63 | 2.63 |
| 402.45 | 2.42 | 2.42 |
| 427.46 | 2.23 | 2.23 |
| 445.45 | 2.36 | 2.36 |
| 402.45 | 2.35 | 2.35 |
| 403.44 | 1.75 | 1.75 |
| 420.44 | 2.49 | 2.49 |
| 458.54 | 1.13 | 1.13 |
| 420.44 | 2.49 | 2.49 |
| 403.44 | 1.75 | 1.75 |
| 461.91 | 2.88 | 2.88 |
| 445.48 | 1.45 | 1.45 |