Basic Information
ID: ALA4026983
Type: Binding
Description: Inhibition of IRAK4 in human KARPAS299 cells assessed as reduction in IL-1 stimulated IRAK4 phosphorylation at Thr345/Ser346 residues preincubated for 1 hr followed by IL-1 stimulation for 10 mins by flow cytometry analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4026983
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 316.47 | 3.46 | 3.46 |
| 343.48 | 3.14 | 3.14 |
| 327.35 | 3.26 | 3.26 |
| 273.38 | 2.55 | 2.55 |
| 315.47 | 3.54 | 3.54 |
| 385.51 | 2.91 | 2.91 |
| 442.56 | 2.96 | 2.96 |
| 386.50 | 2.87 | 2.87 |
| 304.46 | 3.59 | 3.59 |
| 357.50 | 3.16 | 3.16 |
| 329.45 | 3.09 | 3.09 |
| 287.41 | 2.81 | 2.81 |
| 452.60 | 3.13 | 3.13 |
| 313.45 | 3.51 | 3.51 |
| 409.53 | 3.38 | 3.38 |
| 290.44 | 3.28 | 3.28 |
| 426.57 | 2.74 | 2.74 |
| 329.45 | 2.75 | 2.75 |
| 301.44 | 3.37 | 3.37 |
| 273.38 | 2.55 | 2.55 |
| 454.62 | 3.38 | 3.38 |
| 402.56 | 3.59 | 3.59 |
| 299.42 | 2.73 | 2.73 |
| 462.62 | 2.15 | 2.15 |
| 343.48 | 3.14 | 3.14 |
| 299.42 | 3.12 | 3.12 |
| 259.36 | 2.24 | 2.24 |
| 385.51 | 2.91 | 2.91 |
| 290.44 | 3.28 | 3.28 |
| 344.46 | 3.10 | 3.10 |
| 327.48 | 3.90 | 3.90 |
| 276.41 | 2.98 | 2.98 |
| 452.60 | 3.13 | 3.13 |
| 455.61 | 2.87 | 2.87 |
| 384.52 | 3.51 | 3.51 |
| 287.41 | 2.86 | 2.86 |