Basic Information
ID: ALA4027199
Type: Binding
Description: Inhibition of human recombinant GST-tagged Lp-PLA2 (47 to 429 residues) expressed in Escherichia coli Rosetta(DE3) pLysS using 2-thio-PAF as substrate preincubated for 30 min followed by substrate addition measured every minute for 10 mins by DNTB reagent based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4027199
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 666.79 | 7.22 | 7.22 |
| 523.92 | 5.81 | 5.81 |
| 432.46 | 3.98 | 3.98 |
| 532.02 | 6.35 | 6.35 |
| 523.92 | 5.46 | 5.46 |
| 432.50 | 5.39 | 5.39 |
| 497.84 | 5.73 | 5.73 |
| 500.46 | 5.00 | 5.00 |
| 537.95 | 5.66 | 5.66 |
| 425.44 | 4.25 | 4.25 |
| 466.91 | 4.63 | 4.63 |
| 457.51 | 5.26 | 5.26 |
| 496.85 | 5.52 | 5.52 |
| 207.20 | 1.34 | 1.34 |
| 509.89 | 5.78 | 5.78 |
| 517.99 | 6.43 | 6.43 |
| 441.90 | 4.76 | 4.76 |
| 459.89 | 4.90 | 4.90 |
| 471.92 | 4.77 | 4.77 |
| 580.97 | 5.69 | 5.69 |
| 407.45 | 4.11 | 4.11 |
| 467.86 | 5.41 | 5.41 |
| 452.84 | 5.82 | 5.82 |
| 536.96 | 5.23 | 5.23 |
| 466.87 | 6.13 | 6.13 |
| 476.34 | 5.42 | 5.42 |
| 493.44 | 5.27 | 5.27 |
| 456.53 | 5.21 | 5.21 |
| 450.49 | 5.53 | 5.53 |
| 455.92 | 5.07 | 5.07 |