Assay Report Card

Basic Information

ID: ALA4028922

Type: ADME

Description: Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay

Organism: Homo sapiens

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
162.241.851.85
361.371.541.54
232.241.421.42
233.24-0.79-0.79
369.341.701.70
331.351.581.58
319.341.271.27
280.423.883.88
365.842.082.08
303.291.771.77
441.554.374.37
430.382.882.88
267.371.611.61
249.352.152.15
804.034.644.64
314.864.534.53
222.25-0.86-0.86
290.321.261.26
454.615.095.09
398.403.703.70
414.533.373.37
266.340.450.45
180.161.311.31
259.352.582.58
333.453.933.93
252.350.600.60
375.401.981.98
297.75-0.35-0.35
330.751.891.89
250.280.860.86
300.445.605.60
309.334.444.44
253.281.371.37
326.833.723.72
263.383.833.83
299.762.952.95
267.311.671.67
393.474.514.51
303.143.613.61
394.423.703.70
232.281.861.86
359.714.534.53
293.373.133.13
302.241.991.99
395.432.422.42
267.332.852.85
375.874.434.43
340.432.882.88
354.495.655.65
266.302.652.65
341.430.560.56
76.05-0.96-0.96
137.14-0.31-0.31
348.362.082.08
272.371.091.09
441.581.981.98
182.190.070.07
196.681.751.75
369.373.523.52
318.874.894.89
266.393.533.53
232.281.351.35
319.884.814.81
358.854.184.18
234.342.582.58
204.230.830.83
327.381.301.30
282.342.392.39
371.526.006.00
410.493.593.59
299.802.002.00
853.923.743.74
354.493.483.48
305.503.203.20
243.312.532.53
261.091.881.88
276.751.741.74
316.430.500.50
248.331.911.91
308.342.522.52
807.893.263.26
236.302.732.73
198.272.702.70
379.504.364.36
404.554.204.20
274.803.823.82
259.352.782.78
440.954.634.63
214.051.161.16
233.702.252.25
304.223.383.38
187.201.021.02
339.483.363.36
264.322.472.47
333.361.611.61
281.272.382.38
331.351.581.58
428.442.542.54
749.001.901.90
733.941.791.79
306.280.740.74
300.445.605.60
426.494.834.83
223.301.941.94
324.403.813.81
399.442.872.87
236.273.393.39
515.106.486.48
260.251.111.11
179.262.032.03
463.805.945.94
242.703.063.06
151.161.351.35
194.19-1.03-1.03
179.222.042.04
403.983.943.94
238.160.070.07
165.191.451.45
348.401.131.13
310.405.195.19
670.863.093.09
613.802.872.87
567.804.754.75
505.642.402.40
253.270.830.83
381.383.513.51
471.696.456.45
502.800.420.42
575.695.705.70
314.362.562.56
339.393.863.86
387.441.061.06
454.913.963.96
123.11-0.42-0.42
337.351.121.12
383.47-0.31-0.31
481.514.634.63
470.023.553.55
188.231.481.48
278.310.190.19
277.414.174.17
295.411.321.32
341.453.243.24
392.471.901.90
645.326.946.94
277.413.043.04
267.24-0.20-0.20
349.322.182.18
235.331.341.34
284.434.244.24
360.451.561.56
374.481.801.80
265.362.482.48
325.774.324.32
371.282.682.68
287.361.851.85
277.414.214.21
171.160.090.09
189.220.160.16
360.844.684.68
271.08-1.27-1.27
810.993.993.99
367.810.620.62
295.302.972.97
241.293.753.75
446.522.442.44
296.413.613.61
423.431.901.90
141.170.450.45
213.661.861.86
347.463.603.60
387.480.720.72
372.553.813.81
229.26-0.59-0.59
239.311.311.31
312.443.443.44
386.534.664.66
500.632.592.59
406.483.743.74
373.954.584.58
628.814.334.33
211.180.020.02
256.102.012.01
237.732.902.90
234.202.782.78
212.230.620.62
191.95-0.16-0.16
608.694.174.17
389.412.212.21
327.473.373.37
270.351.781.78
317.433.263.26
454.450.270.27
369.473.463.46
209.25-0.13-0.13
230.263.043.04
243.22-2.56-2.56
276.213.213.21
142.16-0.91-0.91
194.15-2.08-2.08
424.524.744.74
246.31-0.28-0.28
320.320.660.66
368.302.012.01
323.813.673.67
416.655.705.70
259.260.030.03
392.412.082.08
305.211.931.93
211.22-0.50-0.50
458.585.355.35
218.260.540.54
246.101.551.55
368.525.115.11
226.232.232.23
314.372.962.96
153.822.552.55
588.561.341.34
410.564.344.34
1202.63
321.340.540.54
247.25-0.46-0.46
470.333.203.20
480.654.944.94
285.372.202.20
337.46-0.77-0.77
335.341.481.48
543.530.000.00
501.482.702.70
395.42-0.17-0.17
390.523.953.95
308.312.762.76
504.64-0.02-0.02
720.965.915.91
446.914.284.28
250.300.450.45
493.624.594.59
211.331.581.58
361.404.114.11
319.412.922.92
305.291.781.78
551.634.204.20
270.213.253.25
296.553.623.62
164.18-0.20-0.20
705.655.585.58
312.412.532.53
339.442.512.51
224.22-0.71-0.71
461.014.274.27
382.894.894.89
469.677.227.22
300.753.373.37
237.25-1.10-1.10
337.381.641.64
197.190.050.05
477.46-0.62-0.62
514.637.267.26
348.496.106.10
261.091.881.88
401.872.732.73
339.39-0.24-0.24
393.361.991.99
248.311.681.68
432.604.194.19
328.431.171.17
307.424.954.95
338.770.920.92
159.231.081.08
418.574.594.59
252.272.642.64
435.534.164.16
268.741.401.40
370.924.794.79
293.324.034.03
287.453.943.94
445.552.082.08
418.975.785.78
262.362.992.99
253.721.721.72
129.160.360.36
365.410.020.02
298.302.752.75
277.371.721.72
179.220.720.72
212.252.982.98
448.394.864.86
313.793.433.43
326.445.175.17
812.024.934.93
409.434.894.89
327.343.053.05
384.25
416.522.382.38
310.834.024.02
176.180.600.60
287.361.921.92
609.746.706.70
259.352.572.57
247.280.530.53
388.821.571.57
448.955.685.68
357.493.343.34
405.501.241.24
303.411.171.17
652.837.457.45
412.536.686.68
452.605.225.22
410.614.274.27
240.312.822.82
170.21-0.13-0.13
473.417.497.49
324.423.173.17
154.12-0.28-0.28
531.444.214.21
324.423.173.17
273.724.164.16
205.260.240.24
255.272.972.97
495.756.886.88
332.313.973.97
557.055.935.93
606.788.688.68
430.542.722.72
169.571.771.77
384.432.602.60
484.50-7.29-7.29
312.453.883.88
435.892.522.52
994.21-3.04-3.04
585.61-8.42-8.42
700.794.574.57
293.372.932.93
307.292.232.23
434.413.203.20
323.421.631.63
563.630.750.75
488.023.313.31
407.322.022.02
288.433.883.88
152.180.640.64
425.923.353.35
230.681.681.68
822.954.344.34
418.452.972.97
392.471.901.90
255.23-1.97-1.97
225.21-1.33-1.33
242.23-1.51-1.51
383.520.090.09
339.37-0.40-0.40
1084.25
312.381.541.54
130.08-0.80-0.80
149.210.110.11
129.17-1.03-1.03
1111.34
516.725.675.67
466.544.354.35
585.660.510.51
444.44-0.21-0.21
236.300.810.81
458.501.981.98
1620.69
424.095.465.46
285.312.662.66
315.684.074.07
180.17-1.04-1.04
433.502.522.52
259.22-2.70-2.70
369.491.291.29
236.23-0.21-0.21
129.09-0.51-0.51
136.110.060.06
200.17-0.02-0.02
847.024.624.62
534.434.954.95
500.584.434.43
318.301.741.74
337.464.224.22
384.263.963.96
265.343.243.24
1155.366.316.31
479.533.683.68
635.523.043.04
408.882.272.27
344.252.112.11
304.322.982.98
764.953.253.25
346.342.182.18
345.422.902.90
434.502.422.42
366.504.314.31
434.502.272.27
114.170.710.71
170.241.381.38
305.342.642.64
388.821.571.57
248.311.961.96
349.525.405.40
293.734.164.16
396.667.647.64
453.46-0.54-0.54
277.271.151.15
424.543.053.05
645.61-8.56-8.56
479.156.456.45
217.290.630.63
289.381.931.93
207.23-3.26-3.26
656.662.752.75
268.27-1.18-1.18
253.353.243.24
575.63-1.40-1.40
420.51-1.60-1.60
309.410.630.63
813.982.772.77
785.896.166.16
285.69-0.30-0.30
425.514.014.01
299.66-1.29-1.29
244.21-3.01-3.01
363.390.150.15
371.392.582.58
437.533.143.14
267.28-4.49-4.49
923.053.523.52
351.474.434.43
843.062.332.33
877.045.655.65
433.963.783.78
276.213.303.30
291.823.723.72
365.833.333.33
218.63-0.23-0.23
300.253.963.96
425.921.351.35
388.423.203.20
666.711.611.61
373.373.713.71
397.524.934.93
747.962.442.44
298.382.842.84
467.52-6.30-6.30
581.475.755.75
303.68-0.35-0.35
225.291.521.52
331.300.010.01
317.37-0.18-0.18
414.344.874.87
753.276.146.14
365.21-1.72-1.72
723.652.462.46
510.48-0.17-0.17
414.503.123.12
419.913.673.67
603.764.114.11
316.383.723.72
414.433.813.81
333.884.634.63
410.401.291.29
441.611.941.94
296.414.034.03
324.903.903.90
469.97
257.761.051.05
236.230.090.09
478.511.761.76
821.14-1.63-1.63
1000.341.791.79
1079.31
1329.48
476.50-0.64-0.64
1243.508.078.07
1129.29
547.591.721.72
332.484.404.40
485.490.970.97
637.745.975.97
435.323.933.93
668.541.101.10
609.694.414.41
665.730.120.12
492.531.601.60
598.096.226.22
810.475.725.72
441.522.372.37
437.902.372.37
732.686.116.11
1269.47
483.973.363.36
473.994.314.31
500.554.434.43
539.55-0.24-0.24
327.904.884.88
492.156.126.12
466.963.923.92
330.313.613.61
493.940.190.19
475.623.043.04
223.752.182.18
329.443.473.47
390.873.823.82
381.432.992.99
435.323.933.93
415.573.153.15
528.546.586.58
579.990.000.00
509.053.813.81
557.610.830.83
391.481.911.91
483.480.090.09
249.99-0.99-0.99
266.310.180.18
451.623.193.19
360.80-0.80-0.80
297.27-1.97-1.97
376.412.292.29
228.21-2.14-2.14
511.51-0.73-0.73
384.524.584.58
267.351.901.90
445.903.773.77
246.29-0.21-0.21
1030.30
513.685.955.95
613.913.123.12
226.23-0.05-0.05
593.237.057.05
441.902.362.36
351.881.161.16
527.665.385.38
369.373.523.52
310.443.663.66
837.062.212.21
193.200.890.89
356.230.400.40
222.192.452.45
412.372.852.85
532.105.275.27
480.90-0.35-0.35
184.283.383.38
429.605.415.41
242.240.090.09
345.851.901.90
420.43-1.04-1.04
298.351.531.53
185.253.573.57
199.99-0.66-0.66
219.630.700.70
320.393.953.95
417.472.812.81
263.363.523.52
371.832.302.30
279.383.963.96
475.585.345.34
457.483.253.25
1001.152.402.40
314.411.461.46
1637.91
469.555.895.89
460.482.222.22
958.246.206.20
540.704.704.70
361.351.801.80
1491.12
385.492.982.98
178.241.561.56
273.331.211.21
446.903.203.20
405.976.566.56
420.492.522.52
1297.30
532.573.333.33
277.24-0.29-0.29
1067.26
883.112.862.86
1219.613.293.29
513.49-0.08-0.08
263.382.632.63
229.230.440.44
382.543.953.95
438.320.920.92
892.03-1.84-1.84
298.433.493.49
4552.00
1287.45
340.464.064.06
821.061.961.96
705.862.152.15
577.58-1.20-1.20
614.65-8.90-8.90
290.11-1.12-1.12
515.520.940.94
295.30-0.83-0.83
315.22-1.66-1.66
740.761.541.54