Assay Report Card

ID: ALA4031093

Type: ADME

Description: Prodrug activation in human Z138 cells assessed as hint1-mediated 2-amino-7-(2-(4-chlorophenoxy)ethyl)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-7-ium formation per 5 million cells at 150 uM after 12 hrs by LC-MS/MS analysis relative to 9-((2R,3R,4S,5R)-5-(((((2-(1H-Indol-3-yl)ethyl)amino)-(hydroxy)phosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-amino-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-6,9-dihydro-1H-purin-7-ium

Organism: Homo sapiens