Basic Information
ID: ALA4031181
Type: Binding
Description: Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presence of ATP and GTP incubated for 1 hr followed by Cy5-labeled cGAMP addition measured after 1 hr by fluorescence polarization assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4031181
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 312.29 | 0.92 | 0.92 |
| 213.20 | 0.89 | 0.89 |
| 312.33 | 1.21 | 1.21 |
| 268.28 | 1.46 | 1.46 |
| 380.40 | 2.48 | 2.48 |
| 298.30 | 0.82 | 0.82 |