Basic Information
ID: ALA4032893
Type: Binding
Description: Allosteric inhibition of SHP2 E76A mutant (unknown origin) expressed in Escherichia coli BL21(DE3) using DIFMUP as substrate preincubated for 20 mins followed by substrate addition measured after 20 mins by phosphatase assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4032893
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 357.91 | 4.93 | 4.93 |
| 352.27 | 3.35 | 3.35 |
| 323.47 | 4.37 | 4.37 |
| 365.50 | 4.50 | 4.50 |
| 367.47 | 3.98 | 3.98 |
| 353.49 | 3.77 | 3.77 |
| 353.49 | 4.29 | 4.29 |
| 329.49 | 4.34 | 4.34 |
| 323.47 | 4.47 | 4.47 |
| 324.45 | 3.68 | 3.68 |
| 367.49 | 4.93 | 4.93 |
| 348.48 | 4.15 | 4.15 |
| 341.46 | 4.42 | 4.42 |
| 365.55 | 5.68 | 5.68 |
| 323.47 | 4.28 | 4.28 |
| 323.47 | 4.14 | 4.14 |
| 374.51 | 4.67 | 4.67 |
| 381.50 | 4.07 | 4.07 |
| 349.50 | 4.79 | 4.79 |
| 315.49 | 4.53 | 4.53 |
| 391.58 | 6.20 | 6.20 |
| 402.36 | 5.04 | 5.04 |
| 295.41 | 3.74 | 3.74 |
| 309.44 | 4.13 | 4.13 |
| 323.47 | 4.15 | 4.15 |
| 407.54 | 4.58 | 4.58 |
| 363.49 | 5.03 | 5.03 |
| 391.58 | 6.20 | 6.20 |