Assay Report Card

Basic Information

ID: ALA4033519

Type: Functional

Description: Ex vivo receptor occupancy at P2X7 in Sprague-Dawley rat assessed as brain drug level causing 50% reduction in [3H]A-804598 receptor labeling in hippocampus at 10 mg/kg, po measured after 2 hrs by radioligand binding autoradiography method

Organism: Rattus norvegicus

Strain: Sprague-Dawley

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
435.844.434.43
425.322.342.34
424.332.942.94
474.795.215.21