Basic Information
ID: ALA4033520
Type: Functional
Description: Ex vivo receptor occupancy at P2X7 in Sprague-Dawley rat assessed as plasma drug level causing 50% reduction in [3H]A-804598 receptor labeling in hippocampus at 10 mg/kg, po measured after 2 hrs by radioligand binding autoradiography method
Organism: Rattus norvegicus
Strain: Sprague-Dawley
Activity Charts
Bioactivity
Activity Types for Assay ALA4033520
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 435.84 | 4.43 | 4.43 |
| 425.32 | 2.34 | 2.34 |
| 424.33 | 2.94 | 2.94 |
| 474.79 | 5.21 | 5.21 |