Basic Information
ID: ALA4035260
Type: ADME
Description: Inhibition of recombinant human COX-2 assessed as reduction in PGH2 production up to 100 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hematin addition measured after 2 mins by ELISA relative to control
Format: BAO_0000357
Organism: Homo sapiens
Target: Cyclooxygenase-2(ALA230)
Document: ALA4033666
Inhibition of recombinant human COX-2 assessed as reduction in PGH2 production up to 100 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hematin addition measured after 2 mins by ELISA relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4035260
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 448.32 | 4.56 | 4.56 |
| 383.46 | 4.11 | 4.11 |
| 387.42 | 3.94 | 3.94 |
| 403.87 | 4.45 | 4.45 |
| 385.43 | 3.51 | 3.51 |
| 414.43 | 3.71 | 3.71 |