Basic Information
ID: ALA4036189
Type: Binding
Description: Inhibition of human 11beta-HSD1 expressed in CHO cell microsomes using [3H]cortisone as substrate preincubated with substrate for 10 mins followed by enzyme addition measured after 90 mins by microbeta scintillation proximity assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4036189
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 455.48 | 5.95 | 5.95 |
| 454.49 | 5.92 | 5.92 |
| 450.35 | 5.55 | 5.55 |
| 470.57 | 5.36 | 5.36 |
| 446.55 | 4.62 | 4.62 |
| 460.57 | 5.01 | 5.01 |
| 460.57 | 5.01 | 5.01 |
| 416.52 | 5.32 | 5.32 |
| 461.56 | 4.41 | 4.41 |
| 524.58 | 6.29 | 6.29 |
| 445.56 | 5.41 | 5.41 |
| 438.42 | 4.91 | 4.91 |
| 446.55 | 5.33 | 5.33 |
| 519.67 | 5.66 | 5.66 |
| 460.57 | 5.72 | 5.72 |
| 416.52 | 5.32 | 5.32 |
| 458.60 | 6.33 | 6.33 |
| 459.36 | 6.33 | 6.33 |
| 445.56 | 5.41 | 5.41 |
| 454.42 | 4.79 | 4.79 |
| 444.58 | 5.94 | 5.94 |
| 434.51 | 5.46 | 5.46 |
| 404.87 | 4.54 | 4.54 |
| 384.45 | 4.20 | 4.20 |
| 473.57 | 4.81 | 4.81 |
| 395.43 | 3.76 | 3.76 |
| 418.44 | 4.35 | 4.35 |
| 388.41 | 4.03 | 4.03 |
| 437.46 | 5.39 | 5.39 |
| 468.52 | 6.18 | 6.18 |
| 435.29 | 4.26 | 4.26 |
| 505.54 | 6.86 | 6.86 |
| 455.56 | 5.58 | 5.58 |
| 513.43 | 4.72 | 4.72 |
| 482.55 | 6.52 | 6.52 |
| 448.54 | 5.85 | 5.85 |
| 449.32 | 4.65 | 4.65 |
| 400.45 | 3.90 | 3.90 |
| 436.43 | 4.49 | 4.49 |
| 416.52 | 5.32 | 5.32 |
| 422.29 | 4.77 | 4.77 |
| 419.47 | 5.25 | 5.25 |
| 445.56 | 5.41 | 5.41 |