Basic Information
ID: ALA4040508
Type: Functional
Description: Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 30 mins by Topcount scintillation counting method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4040508
EC80
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.57 | 6.79 | 6.79 |
| 333.43 | 3.51 | 3.51 |
| 487.48 | 3.50 | 3.50 |
| 373.29 | 5.23 | 5.23 |
| 358.85 | 4.96 | 4.96 |
| 504.98 | 6.52 | 6.52 |
| 450.89 | 5.61 | 5.61 |
| 418.93 | 6.11 | 6.11 |
| 451.88 | 5.58 | 5.58 |
| 460.43 | 5.89 | 5.89 |
| 408.86 | 5.84 | 5.84 |
| 419.92 | 5.02 | 5.02 |
| 468.45 | 6.57 | 6.57 |
| 406.84 | 5.60 | 5.60 |
| 431.37 | 5.37 | 5.37 |
| 439.35 | 6.46 | 6.46 |
| 422.89 | 5.95 | 5.95 |
| 402.47 | 5.60 | 5.60 |
| 472.44 | 5.49 | 5.49 |
| 434.90 | 6.21 | 6.21 |
| 430.53 | 6.42 | 6.42 |
| 459.30 | 5.52 | 5.52 |
| 464.92 | 5.29 | 5.29 |
| 464.92 | 5.74 | 5.74 |
| 454.45 | 5.35 | 5.35 |
| 465.90 | 5.70 | 5.70 |
| 456.44 | 6.31 | 6.31 |
| 460.28 | 5.49 | 5.49 |
| 422.89 | 5.89 | 5.89 |
| 390.38 | 5.08 | 5.08 |
| 392.40 | 5.33 | 5.33 |
| 418.32 | 5.21 | 5.21 |
| 356.83 | 4.72 | 4.72 |
| 426.88 | 5.53 | 5.53 |
| 456.44 | 6.31 | 6.31 |
| 471.46 | 5.52 | 5.52 |
| 475.47 | 4.49 | 4.49 |
| 417.34 | 5.25 | 5.25 |
| 408.86 | 5.64 | 5.64 |
| 453.47 | 5.38 | 5.38 |
| 450.82 | 6.10 | 6.10 |
| 460.28 | 5.49 | 5.49 |
| 472.90 | 6.83 | 6.83 |
| 442.42 | 6.00 | 6.00 |
| 464.92 | 5.74 | 5.74 |