Basic Information
ID: ALA4040855
Type: Binding
Description: Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV at 0.01 to 10 uM preincubated for 30 secs followed by GABA stimulation for 2 secs by automated patch clamp assay relative to GABA
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4040855
Emax
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 318.50 | 4.60 | 4.60 |
| 384.56 | 4.47 | 4.47 |
| 385.55 | 3.87 | 3.87 |
| 399.58 | 4.18 | 4.18 |
| 427.59 | 3.57 | 3.57 |
| 410.56 | 3.74 | 3.74 |
| 398.59 | 4.78 | 4.78 |
| 409.57 | 4.34 | 4.34 |
| 398.59 | 4.78 | 4.78 |
| 399.58 | 4.18 | 4.18 |
| 414.59 | 4.48 | 4.48 |
| 439.60 | 3.97 | 3.97 |
| 419.01 | 5.13 | 5.13 |
| 429.56 | 4.38 | 4.38 |
| 410.56 | 3.74 | 3.74 |
| 428.57 | 4.17 | 4.17 |
| 423.60 | 4.73 | 4.73 |
| 398.59 | 4.78 | 4.78 |
| 452.56 | 5.49 | 5.49 |
| 399.58 | 4.18 | 4.18 |
| 409.57 | 4.34 | 4.34 |