Basic Information
ID: ALA4043761
Type: Functional
Description: Neuroprotective activity against fibril amyloid beta (25 to 35)-induced cell death in Sprague-Dawley rat 5 day old neonatal primary cortical neurons assessed as cell death at maximum non toxic concentration pretreated for 2 hrs followed by 10 uM fibril amyloid beta (25 to 35) addition measured after 48 hrs by MTT assay (Rvb = 39.20 +/- 0.88%)
Format: BAO_0000219
Organism: Rattus norvegicus
Strain: Sprague-Dawley
Cell type: Cortical neurone
Target: Cortical neurone(ALA5314313)
Document: ALA4043092
Neuroprotective activity against fibril amyloid beta (25 to 35)-induced cell death in Sprague-Dawley rat 5 day old neonatal primary cortical neurons assessed as cell death at maximum non toxic concentration pretreated for 2 hrs followed by 10 uM fibril amyloid beta (25 to 35) addition measured after 48 hrs by MTT assay (Rvb = 39.20 +/- 0.88%): 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4043761
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 312.28 | 3.18 | 3.18 |
| 321.13 | 3.98 | 3.98 |
| 337.12 | 3.68 | 3.68 |
| 321.13 | 3.98 | 3.98 |
| 321.13 | 3.98 | 3.98 |
| 356.33 | 3.50 | 3.50 |
| 340.33 | 3.79 | 3.79 |
| 305.13 | 4.27 | 4.27 |
| 412.44 | 4.19 | 4.19 |
| 365.22 | 4.35 | 4.35 |
| 326.35 | 3.55 | 3.55 |
| 368.39 | 3.88 | 3.88 |
| 314.34 | 3.61 | 3.61 |
| 270.28 | 3.30 | 3.30 |
| 270.28 | 3.30 | 3.30 |
| 398.46 | 4.47 | 4.47 |
| 365.22 | 4.35 | 4.35 |
| 414.45 | 4.17 | 4.17 |
| 444.12 | 5.11 | 5.11 |
| 368.43 | 4.46 | 4.46 |
| 365.22 | 4.35 | 4.35 |
| 368.39 | 3.88 | 3.88 |
| 284.31 | 3.60 | 3.60 |
| 354.40 | 4.16 | 4.16 |
| 347.16 | 4.60 | 4.60 |
| 368.43 | 4.46 | 4.46 |
| 324.33 | 4.09 | 4.09 |
| 368.39 | 3.88 | 3.88 |
| 314.34 | 3.40 | 3.40 |
| 428.48 | 4.48 | 4.48 |
| 352.39 | 4.17 | 4.17 |
| 384.43 | 4.16 | 4.16 |
| 326.35 | 3.55 | 3.55 |
| 384.43 | 4.16 | 4.16 |
| 326.30 | 3.27 | 3.27 |
| 349.18 | 4.06 | 4.06 |