Basic Information
ID: ALA4045603
Type: Binding
Description: Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-LRRKtide substrate addition after 2 hrs by TR-FRET assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4045603
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 443.40 | 3.29 | 3.29 |
| 377.45 | 3.09 | 3.09 |
| 364.45 | 3.01 | 3.01 |
| 333.40 | 3.25 | 3.25 |
| 319.37 | 3.99 | 3.99 |
| 332.41 | 3.66 | 3.66 |
| 317.35 | 3.74 | 3.74 |
| 378.48 | 3.00 | 3.00 |
| 392.51 | 3.04 | 3.04 |
| 292.34 | 3.57 | 3.57 |
| 264.33 | 3.04 | 3.04 |
| 265.32 | 2.53 | 2.53 |
| 291.31 | 3.17 | 3.17 |
| 305.34 | 3.42 | 3.42 |
| 278.36 | 3.52 | 3.52 |
| 265.32 | 3.60 | 3.60 |
| 250.31 | 3.03 | 3.03 |
| 303.37 | 3.22 | 3.22 |
| 289.34 | 3.21 | 3.21 |
| 291.31 | 3.17 | 3.17 |
| 264.33 | 3.04 | 3.04 |